Effect of the pairing gene Ph1 on centromere misdivision in common wheat.

Genetics
J M Vega, M Feldman

Abstract

The cytologically diploid-like meiotic behavior of hexaploid wheat (i.e., exclusive bivalent pairing of homologues) is largely controlled by the pairing homoeologous gene Ph1. This gene suppresses pairing between homoeologous (partially homologous) chromosomes of the three closely related genomes that compose the hexaploid wheat complement. It has been previously proposed that Ph1 regulates meiotic pairing by determining the pattern of premeiotic arrangement of homologous and homoeologous chromosomes. We therefore assume that Ph1 action may be targeted at the interaction of centromeres with spindle microtubules--an interaction that is critical for movement of chromosomes to their specific interphase positions. Using monosomic lines of common wheat, we studied the effect of this gene on types and rates of centromere division of univalents at meiosis. In the presence of the normal two doses of Ph1, the frequency of transverse breakage (misdivision) of the centromere of univalent chromosomes was high in both first and second meiotic divisions; whereas with zero dose of the gene, this frequency was drastically reduced. The results suggest that Ph1 is a trans-acting gene affecting centromere-microtubules interaction. The findings ar...Continue Reading

References

Jan 1, 1976·Annual Review of Genetics·E R Sears
Dec 1, 1991·Current Opinion in Genetics & Development·H F Willard
Jun 1, 1991·The Journal of Cell Biology·R P ZinkowskiB R Brinkley
Jan 1, 1991·Cell Motility and the Cytoskeleton·D WiseE D Salmon
Dec 1, 1990·Genome Génome / Conseil National De Recherches Canada·J Loidl
Oct 18, 1972·Nature: New Biology·T Rajhathy, H Thomas
Jun 1, 1966·Proceedings of the National Academy of Sciences of the United States of America·M Feldman
Oct 1, 1966·Proceedings of the National Academy of Sciences of the United States of America·M FeldmanE R Sears
Feb 1, 1984·Genetics·J E Haber, P C Thorburn
Nov 15, 1984·Nature·T Mitchison, M Kirschner
Jan 1, 1980·Human Genetics·L Avivi, M Feldman
Nov 1, 1995·The Journal of Cell Biology·Y ZhaiG G Borisy
Jan 1, 1995·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·A HoubenM Schmid
Jan 1, 1993·Cold Spring Harbor Symposia on Quantitative Biology·N Kleckner, B M Weiner
Aug 6, 1996·Proceedings of the National Academy of Sciences of the United States of America·N Kleckner
Nov 1, 1996·Genetics·M C LuoJ Dvorák
Dec 1, 1996·Chromosoma·L Aragón-AlcaideG Moore
Nov 26, 1996·Proceedings of the National Academy of Sciences of the United States of America·J JiangD C Ward
Jul 3, 1995·Proceedings of the National Academy of Sciences of the United States of America·J DubcovskyJ Dvorak
Jan 1, 1952·Chromosoma·E R SEARS
Jan 1, 1973·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·T Mello-Sampayo

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Citations

Feb 26, 2000·Annual Review of Genetics·D Zickler, N Kleckner
Mar 9, 2005·Cytogenetic and Genome Research·X-F Ma, J P Gustafson
Nov 9, 2012·Genetics·Moshe Feldman, Avraham A Levy

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