Effect of the Pl(A2) alloantigen on the function of beta(3)-integrins in platelets.

Blood
J S BennettG A FitzGerald

Abstract

The polymorphism responsible for the Pl(A2) alloantigen on the beta(3)-component of beta(3)-containing integrins is reported to be a risk factor for coronary thrombosis. This study examined the effect of Pl(A2) on the function of beta(3)-integrins using platelets from subjects homozygous and heterozygous for Pl(A1) and Pl(A2). There was overlap in the distribution of the dissociation constant (K(d)) and maximum fibrinogen binding (B(max)) values for fibrinogen binding to alpha(IIb)beta(3) on platelets from Pl(A1) and Pl(A2) homozygotes and Pl(A1)/Pl(A2) heterozygotes. However, whereas there was no statistical difference in these values for the Pl(A1) homozygotes and Pl(A2) heterozygotes, the K(d) for the Pl(A2) homozygotes was significantly lower than that for the Pl(A1)/Pl(A2) heterozygotes, but was not statistically different from that for the Pl(A1) homozygotes. No differences were detected in ADP sensitivity between platelets from Pl(A1) homozygotes and Pl(A1)/Pl(A2) heterozygotes, in the IC(50) for RGDS inhibition of fibrinogen binding to alpha(IIb)beta(3), in the alpha(v)beta(3)-mediated adhesion of platelets to osteopontin and vitronectin, and in the phorbol ester-stimulated adhesion to fibrinogen of B lymphocytes expres...Continue Reading

References

Nov 1, 1979·The Journal of Clinical Investigation·J S Bennett, G Vilaire
May 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·J S BennettD B Cines
Apr 25, 1996·The New England Journal of Medicine·E J WeissP J Goldschmidt-Clermont
Apr 25, 1996·The New England Journal of Medicine·R I Handin
Oct 3, 1996·The New England Journal of Medicine·A J MarianN S Kleiman
Mar 28, 1997·The Journal of Biological Chemistry·J S BennettW F DeGrado
Mar 1, 1997·Cardiovascular Research·N J Samani, D Lodwick
Jul 1, 1997·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·J CorralV Vicente
May 14, 1998·Seminars in Thrombosis and Hemostasis·E F MammenD J Nugent
Jun 27, 1998·Lancet·G E CookeP J Goldschmidt-Clermont
Jul 3, 1998·European Journal of Clinical Investigation·L ScaglioneP Cavallo-Perin
Jul 22, 1998·Arteriosclerosis, Thrombosis, and Vascular Biology·A M CarterP J Grant
Mar 18, 1999·Journal of the American College of Cardiology·J L AndersonJ F Carlquist
Apr 9, 1999·Arteriosclerosis, Thrombosis, and Vascular Biology·D FengG H Tofler
Jun 3, 1999·British Journal of Haematology·D J MeiklejohnM Greaves
Mar 23, 2000·The Journal of Clinical Investigation·K V VijayanP F Bray
Jul 18, 2000·Journal of the American College of Cardiology·A KastratiA Schömig
Oct 12, 2000·Journal of the American College of Cardiology·J MikkelssonP J Karhunen
Jan 1, 1996·Trends in Cardiovascular Medicine·J S Bennett

❮ Previous
Next ❯

Citations

Dec 21, 2004·Breast Cancer Research and Treatment·Shan Wang-Gohrke, Jenny Chang-Claude
Dec 1, 2005·Breast Cancer Research and Treatment·Uwe LangsenlehnerPeter Krippl
Aug 8, 2002·Thrombosis Research·Artur-Aron WeberKarsten Schrör
Aug 7, 2003·Journal of the National Cancer Institute·Stig E BojesenBørge G Nordestgaard
Aug 13, 2002·Current Opinion in Hematology·Emmanuel J Favaloro
Aug 9, 2012·Current Opinion in Hematology·Thomas J KunickiDiane J Nugent
Jan 16, 2007·Journal of Medical Genetics·Anna JakubowskaUte Hamann
Apr 13, 2013·Circulation Research·Kamila BledzkaEdward F Plow
Nov 28, 2001·Pharmacogenomics·M J Quinn, E J Topol
Jan 9, 2008·Blood Reviews·Isabelle I SallesHans Deckmyn
Jun 24, 2004·Vox Sanguinis·H DeckmynK Vanhoorelbeke
Sep 24, 2004·Journal of Biomedical Materials Research. Part a·P RazZ Schwartz
Apr 26, 2006·Journal of Thrombosis and Haemostasis : JTH·K V VijayanP F Bray
Jul 10, 2013·British Journal of Clinical Pharmacology·Christopher N Floyd, Albert Ferro
Sep 13, 2005·La Revue de médecine interne·P Fontana, J-L Reny
Apr 9, 2008·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·J McCaslinG Stansby
Sep 12, 2009·Journal of the American College of Cardiology·Francisco MarínDominick J Angiolillo
Jul 9, 2010·Blood·Thomas J Kunicki, Diane J Nugent
Oct 20, 2012·PloS One·Haixia NiuJunling Liu
Feb 10, 2016·JRSM Cardiovascular Disease·Christopher N FloydTimothy D Warner
Apr 12, 2005·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Jussi MikkelssonPekka J Karhunen
Oct 22, 2014·World Journal of Methodology·Pooja JoshiMichela Garofalo
Dec 5, 2009·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Firdos AhmadRenu Saxena
Jul 19, 2018·Blood·Dongwen ZhouJieqing Zhu
Dec 17, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·Luca PontiggiaJuerg H Beer
Apr 25, 2003·Vascular Medicine·Frederick L Ruberg, Joseph Loscalzo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.