PMID: 11934526Apr 6, 2002Paper

Effect of the preovulatory LH surge on bovine follicular progesterone receptor mRNA expression

Domestic Animal Endocrinology
Carolyn A CassarGeorge W Smith

Abstract

A growing body of evidence indicates that intrafollicular progesterone receptor signaling pathways are obligatory for follicle rupture. However, the intrafollicular localization and regulation of progesterone receptor expression during the periovulatory period in cattle are not known. In this study, we determined the effect of the preovulatory gonadotropin surge on localization and expression of progesterone receptor mRNA in bovine periovulatory follicular and luteal tissue. Ovaries containing preovulatory follicles or new corpora lutea (CL) were collected at approximately 0, 6, 12, 18, 24 (preovulatory follicles) and 48 h (CL) after a GnRH-induced LH surge (n=5-8 per timepoint). Expression of progesterone receptor mRNA was detected in periovulatory follicular and luteal tissue at all timepoints examined. Relative levels of progesterone receptor mRNA were dramatically upregulated within 6h after the LH surge compared to all other time points (P<0.0001). In situ hybridization analysis revealed that the significant increase in progesterone receptor mRNA expression was localized to the granulosal layer of preovulatory follicles. Our results indicate that progesterone receptor mRNA expression is upregulated specifically in the gran...Continue Reading

References

Aug 1, 1990·Endocrinology·Y A Chandrasekher, J E Fortune
Jun 1, 1989·Biology of Reproduction·M Brännström, P O Janson
Jul 1, 1984·Proceedings of the Society for Experimental Biology and Medicine·B W SnyderH P Schane
Sep 15, 1995·Genes & Development·J P LydonB W O'Malley
Dec 19, 1995·Proceedings of the National Academy of Sciences of the United States of America·G LeonardssonT Ny
Feb 5, 1996·Molecular and Cellular Endocrinology·A K BerndtsonJ E Fortune
Mar 5, 1996·Proceedings of the National Academy of Sciences of the United States of America·M L HibbertM B Zelinski-Wooten
Nov 1, 1995·Theriogenology·J R PursleyM C Wiltbank

❮ Previous
Next ❯

Citations

Jun 5, 2002·Molecular and Cellular Endocrinology·Michael F SmithGeorge W Smith
Oct 20, 2012·Reproduction : the Official Journal of the Society for the Study of Fertility·Natalia R SalvettiHugo H Ortega
Dec 8, 2004·Reproduction : the Official Journal of the Society for the Study of Fertility·Monica A StoopsTerri L Roth
Oct 29, 2004·Reproduction : the Official Journal of the Society for the Study of Fertility·Qinglei LiGeorge W Smith
May 4, 2011·Research in Veterinary Science·Natalia S AlfaroHugo H Ortega
Mar 15, 2015·Reproduction : the Official Journal of the Society for the Study of Fertility·Hugo H OrtegaNatalia R Salvetti
Jun 12, 2004·Endocrinology·Mark PacigaGraham F Wagner
Jul 24, 2004·Endocrinology·Susan M QuirkRebecca M Harman
Aug 26, 2021·Human Reproduction Update·Alexa BishopGuy S Whitley

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.