PMID: 8957549Jan 1, 1996Paper

Effect of the renin-angiotensin-aldosterone system on the cardiac interstitium in heart failure

Basic Research in Cardiology
A WilkeC G Brilla

Abstract

The interaction of the renin-angiotensin-aldosterone system (RAAS) and cardiac growth is of great interest in chronic heart failure. The pressure or volume overloaded heart shows a hypertrophic growth of the myocardium, i.e., an enlargement of cardiac myocytes. In addition, cardiac fibroblast activation is responsible for the accumulation of fibrillar type I and type III collagens within the interstitium and adventitia of intramyocardial coronary arteries. This remodeling of the cardiac interstitium represents a major determinant of pathological hypertrophy in that it accounts for abnormal myocardial stiffness, leading to ventricular diastolic and systolic dysfunction and ultimately the appearance of symptomatic heart failure. The growth of cardiac fibroblasts is not primarily regulated by the hemodynamic load. In vivo and in vitro studies suggest that the effector hormones, angiotensin II and aldosterone, of the RAAS are primarily involved in regulating the structural remodeling of the myocardial collagen matrix. In cultured adult cardiac fibroblasts, angiotensin II and aldosterone has been shown to stimulate collagen synthesis while angiotensin II additionally inhibits matrix metalloproteinase I activity, which is the key enz...Continue Reading

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Citations

Oct 3, 2001·Physiological Reviews·L H SnoeckxG J Van Der Vusse
Aug 3, 2002·Hypertension·John C BarbatoRoberto Franco-Saenz
Sep 25, 2003·Physiological Reviews·Derek M Yellon, James M Downey
Dec 14, 2004·The Journal of Biological Chemistry·Jiaxu WangChristopher A McCulloch
Mar 24, 2009·Liver International : Official Journal of the International Association for the Study of the Liver·Masato YonedaAtsushi Nakajima
Jul 27, 2017·Canadian Journal of Physiology and Pharmacology·Aleksandra VranicDusan Djuric
Aug 3, 2000·American Journal of Physiology. Heart and Circulatory Physiology·J W MockridgeR J Heads
Jul 5, 2003·American Journal of Physiology. Heart and Circulatory Physiology·J WangC A McCulloch
Jun 26, 2007·Nature Clinical Practice. Cardiovascular Medicine·Srinivasa R KalidindiGary S Francis
Feb 17, 2001·American Journal of Physiology. Heart and Circulatory Physiology·H H PatelG J Gross
Feb 7, 2013·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Danielle Co CoutinhoAnderson J Ferreira
May 17, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Tony KarramZaid Abassi
Sep 20, 2000·American Journal of Physiology. Heart and Circulatory Physiology·R R MorrisonG P Matherne
Aug 12, 1998·The Journal of Surgical Research·K BaghelaiA S Wechsler

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