Effect of the reporting-interval size on critical difference estimation: beyond "2.77"

Clinical Chemistry
Graham Ross Dallas Jones

Abstract

The reporting interval is the bin size used to report numerical pathology results and must be determined for every analyte. The influence of the size of the reporting interval on the critical difference (CD) between two results from the same patient has not been addressed previously. The effect of changing the reporting-interval size (RIS) on CDs was modeled by use of a spreadsheet application. The findings were applied to data on CDs with analytical precision values from our laboratory. As the RIS increases relative to the combined analytical and within-person biological variation, there is an approximately linear increase in the CD from the value determined by use of published techniques. The revised estimate is as follows: CD = 2(1/2) x z x (SDa(2) + SDi(2))(1/2) + 1.5 x RIS, where CD, SD, and RIS are all in the same units. This effect is seen for any probability associated with the critical difference and for both uni- and bidirectional changes. The choice of reporting interval should be made in the light of assay requirements. Where there is a clinical need for detection of small changes in analyte concentration, the reporting interval should be kept small relative to the combined variation attributable to assay precision ...Continue Reading

References

Aug 31, 2004·Annals of Clinical Biochemistry·Tony BadrickPeter E Hickman
Oct 23, 2004·Clinical Chemistry and Laboratory Medicine : CCLM·Sarela García-SantamarinaXavier Fuentes-Arderiu

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Citations

Dec 14, 2007·Clinical Chemistry and Laboratory Medicine : CCLM·Per Hyltoft PetersenLone G M Jørgensen
Jan 20, 2012·Journal of the American Veterinary Medical Association·Brice S ReynoldsCatherine Trumel
Apr 17, 2008·Critical Reviews in Clinical Laboratory Sciences·Samuel D Vasikaran
Dec 3, 2015·Annals of Clinical Biochemistry·Graham R D Jones, Jason Z Y Chung
Apr 26, 2017·Annals of Clinical Biochemistry·Graham Rd Jones, Jason Zy Chung
Jun 14, 2019·Veterinary Clinical Pathology·A Russell Moore, Kathleen Freeman
Jun 17, 2021·Critical Reviews in Clinical Laboratory Sciences·Paul R JohnsonJ Rex Astles

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