PMID: 8946579Oct 1, 1996Paper

Effect of the route and mode of agonist delivery on functional behaviour of the airways

Respiration Physiology
F G Salerno, M S Ludwig

Abstract

There is evidence that the mode of smooth muscle agonist delivery affects the changes induced in lung mechanical properties. The object of this investigation was to study modifications in airway behaviour associated with different modes of agonist delivery. Tracheal (Ptr) and alveolar pressure (PA) and flow (V) were measured in open-chested, mechanically ventilated (f = 1 Hz, VT = 10 ml/kg, PEEP = 4 cm H2O) rats under baseline conditions and during administration of repeated intravenous (i.v.) bolus, i.v. continuous infusion and aerosols of methacholine (MCh). We calculated lung elastance (EL) and lung resistance (RL) by fitting the equation of motion to changes in Ptr and V. We assessed the patency of the airway pathways and local dynamic hyperinflation by comparing Ptr vs PA. Comparison of the three different modes of MCh delivery showed a difference in the functional behaviour of the airways. In the aerosol group a larger incidence of highly constricted airways was observed. Conversely, the i.v. groups showed a larger incidence of regional dynamic hyperinflation. In the bolus group a different time course in the development of dynamic hyperinflation was observed for different pathways within the same animal. For consecutive ...Continue Reading

References

Mar 1, 1992·The American Review of Respiratory Disease·D O Warner, S J Gunst
Feb 1, 1989·The American Review of Respiratory Disease·C S KimM A Sackner
Feb 1, 1994·American Journal of Respiratory and Critical Care Medicine·B GastonJ S Stamler

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Citations

Jan 13, 2009·Respiratory Physiology & Neurobiology·Sofia JonassonJosephine Hjoberg
Mar 19, 2020·Experimental Biology and Medicine·Renato de L VitorassoHenrique T Moriya
May 1, 1997·Journal of Applied Physiology·D W KaczkaK R Lutchen
Jul 3, 2013·Journal of Applied Physiology·David W KaczkaRobert H Brown
Oct 29, 2000·Journal of Applied Physiology·A M Lauzon, J H Bates
Feb 20, 2021·Experimental Biology and Medicine·Maria A OliveiraRenato L Vitorasso
Jun 2, 2021·Respiratory Physiology & Neurobiology·Renato Lima VitorassoHenrique Takachi Moriya

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