PMID: 6104680Apr 1, 1980Paper

Effect of the somatostatin analog D-Trp8,D-Cys14 on glucose insulin, pancreatic glucagon and growth hormone plasma levels in acromegalics and mild diabetics

Journal of Endocrinological Investigation
M TrovatiG F Pagano

Abstract

The effect of the somatostatin analog (GHRIH-A) D-Trp8, D-Cys14 on plasma levels of growth hormone, pancreatic glucagon, insulin and glucose was studied in four acromegalic patients and in four maturity-onset mild diabetics. Acromegalics received a bolus iv injection of 25 microgram of GHRIH-A, followed by a continuous infusion of 25 microgram in saline over an hour. Mild diabetics were submitted in two different days to two tests: arginine (30 g in 30 min) +/- GHRIH-A (bolus iv injection of 25 microgram followed by an infusion of 25 microgram/h over 120 min) and arginine + saline. GHRIH-A lead to a significant (2 p less than 0.01) fall in GH basal secretion in acromegalics, and significantly reduced the GH response to arginine in maturity-onset diabetics. The inhibitory effect of insulin secretion was less impressive, but significative in both groups. No significant changes in plasma pancreatic glucagon values were noted. In mild diabetics, GHRIH-A infusion induced a small but significant increase in the blood glucose increment due to arginine. Our data suggest that this somatostatin analog may be potentially useful only when GH suppression is the main therapeutic goal to be reached, as in acromegaly and in severe diabetic ret...Continue Reading

References

Oct 1, 1978·Diabetes·S E ChristensenK Lundbaek
Nov 1, 1978·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·V SchusdziarraR Unger
Jan 24, 1977·Biochemical and Biophysical Research Communications·C MeyersF Labrie
May 1, 1977·The Journal of Clinical Endocrinology and Metabolism·W WaldhäuslE Deutsch
Jan 1, 1976·Clinical Endocrinology·D SarantakisN H Grant
Dec 1, 1975·Diabetologia·A S LuyckxP J Lefebvre

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Citations

Nov 28, 2015·Nature Reviews. Endocrinology·Shlomo Melmed
Aug 1, 1984·Journal of Endocrinological Investigation·C RedekoppR A Donald

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