PMID: 696788Sep 1, 1978Paper

Effect of the specific angiotensin antagonist (Sar1) (Ala8) angiotensin II on blood pressure and the renin-angiotensin system in the conscious pregnant ewe and fetus

American Journal of Obstetrics and Gynecology
F Broughton Pipkin, P M O'Brien

Abstract

A direct relationship was found between maternal diastolic blood pressure and simultaneously measured angiotensin II (All) levels (P less than 0.001) in chronically cannulated pregnant ewes. The infusion of Saralasin to the ewe resulted in a dose-dependent fall in blood pressure (P less than 0.005), the magnitude of which was proportional to the initial All levels (P less than 0.025). Plasma renin and All levels rose significantly during the infusion. No consistent fetal effects were seen. The infusion of normal saline had no effect on blood pressure or hormone levels. Thus it seems likely that the renin-angiotensin system is involved with the maintenance of normal blood pressure in the pregnant sheep. Fetal blood pressure either fell significantly or was unchanged following direct infusion of Saralasin. This may be related to development of the beta-adrenergic nervous system. The renin-angiotensin system may be more important in cardiovascular homeostasis in the immature than in the adult animal.

Citations

Oct 1, 1993·British Journal of Pharmacology·E R LumbersA D Stevens
Jan 1, 1980·Clinical and Experimental Hypertension : CHE·M K McLaughlin, R A Chez
Jul 1, 1984·Equine Veterinary Journal·F Broughton Pipkin
Mar 1, 1981·Clinical and Experimental Pharmacology & Physiology·W B Lee, E R Lumbers
Feb 1, 1986·British Journal of Clinical Pharmacology·R Soares de Moura, N Solano Vale
Mar 1, 1983·British Journal of Obstetrics and Gynaecology·H J Tetlow, F Broughton Pipkin
Sep 15, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·C R Rosenfeld
Oct 1, 1988·Cell Biochemistry and Function·P GhianiM A Masini
Apr 1, 1979·British Journal of Obstetrics and Gynaecology·F Broughton PipkinE M Symonds
Apr 1, 1989·The American Journal of Physiology·R R Magness, C R Rosenfeld
Nov 1, 1992·The American Journal of Physiology·L E DavisC R Rosenfeld
Aug 1, 1980·Kidney International·C W Redman

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