Abstract
We compared the cytotoxic activities of dietary epoxylignans and their stereoisomers and found (-)-verrucosin, which is (7S,7'R,8R,8'R)-7,7'-epoxylignan, to be the most cytotoxic epoxylignan against HeLa cells (IC50 = 6.6 μM). On the other hand, the activity was about a factor of 10 less against HL-60. In this research on the relationship between the structure and cytotoxic activity of (-)-verrucosin 13, the 7-(4-methoxyphenyl)-7'-(3,4-dimethoxyphenyl) derivative 60, for which the activity (IC50 = 2.4 μM) is three times greater than (-)-verrucosin 13, was discovered. The induction of apoptosis by caspase 3/7 was observed upon treatment with the (-)-verrucosin derivative.
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Jan 20, 2018·Oncotarget·Jun LuoMingyuan Li
Nov 14, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hisashi NishiwakiSatoshi Yamauchi
May 4, 2020·Bioorganic & Medicinal Chemistry Letters·Satoshi YamauchiTakuya Sugahara
Feb 25, 2021·Organic & Biomolecular Chemistry·Tatsuaki TakuboSatoshi Yamauchi