Effect of the sulphonylurea glibenclamide on liver and kidney antioxidant enzymes in streptozocin-induced diabetic rats

Drugs in R&D
E ElmaliN Bukan

Abstract

Alterations in catalase (CAT) and superoxide dismutase (SOD) activity have been reported in diabetes mellitus. Glibenclamide (glyburide), a member of the second-generation sulphonylureas, provides effective treatment for patients with moderate diabetes. The action of the liver plays an important role in its glucose-lowering effect, suggesting that glibenclamide also exerts a direct effect on liver enzyme activities. To evaluate the effect of glibenclamide on the activities of antioxidant enzymes (CAT and SOD) in liver and kidney tissue of diabetic rats. Thirty-nine rats were included in this study. Moderate diabetes mellitus was induced with streptozocin (freshly dissolved in citrate buffer, ph 4.5) 55 mg/kg in 22 rats. Eight of these diabetic rats were left untreated, insulin was administered to six diabetic rats, and glibenclamide was administered to eight rats with moderate diabetes. Liver and kidney CAT and SOD activities were measured in all rats. Hepatic CAT and SOD activities were significantly reduced in diabetic animals (p < 0.05 for both activities). Glibenclamide treatment of diabetic rats for 5 weeks reversed the changes observed in diabetic liver tissues (p < 0.05). However, renal CAT and SOD activities were unchan...Continue Reading

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Citations

Sep 16, 2014·International Journal of Cancer. Journal International Du Cancer·Walter Lemmo
Dec 3, 2011·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Fenglin LiXiangle Meng
Jul 15, 2015·Journal of Diabetes and Metabolic Disorders·Ozra Tabatabaei-MalazyMohammad Abdollahi
Jul 24, 2010·Pflügers Archiv : European journal of physiology·Gisela DrewsMartina Düfer
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May 23, 2016·BMC Complementary and Alternative Medicine·Muhammad TaherZainul Amiruddin Zakaria
Aug 24, 2007·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Parisa SarkhailMohammad Abdollahi

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