Effect of the Yang tonifying herbs on myocardial beta-adrenoceptors of hypothyroid rabbits

Journal of Ethnopharmacology
X MinO Ming

Abstract

New Zealand White female rabbits were randomly divided into three groups, each contained six rabbits, i.e. thyroidectomized and untreated rabbits (group 1), thyroidectomized rabbits treated by the Yang tonifying herbs (group 2) and sham thyroidectomized rabbits as controls (group 3). The myocardial beta-adrenoceptor density (Bmax) and affinity (Kd) of each group of rabbits were determined by radioligand binding assay technique on the thirtieth postoperative day and the data were handled by using a computer program of the Woolf plot with weight regression. Moreover, the serum levels of thyroxine (T4) and triiodothyronine (T3) of each group of rabbits were measured by radioimmunoassay technique and their heart rates (HR) were also recorded on the preoperative and thirtieth postoperative day. The results showed that the Bmax, T4, T3 and HR in group 1 were lower significantly than that in group 3 (P < 0.01-0.001), but the change of Kd in group 1 was not significant; the deviation of the indices from the normal value in group 2 was less remarkably than in group 1 other than T4.

References

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Citations

Dec 21, 2007·Chinese Medicine·Ricky W K WongUrban Hägg
Jan 5, 2011·Journal of Ethnopharmacology·Xiao Ying TianMichael Wong
Jan 10, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Yunke ZhangFeng Gao

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