Effect of Thiamine Administration on Lactate Clearance and Mortality in Patients With Septic Shock

Critical Care Medicine
Jordan A WoolumAlexander H Flannery

Abstract

Mounting evidence has shown that critically ill patients are commonly thiamine deficient. We sought to test the hypothesis that critically ill patients with septic shock exposed to thiamine would demonstrate improved lactate clearance and more favorable clinical outcomes compared with those not receiving thiamine. Retrospective, single-center, matched cohort study. Tertiary care academic medical center. Adult patients admitted with an International Classification of Diseases, 9th Edition, or International Classification of Diseases, 10th Edition, diagnosis code of septic shock to either the medicine or surgery ICU. None. Patients who received IV thiamine supplementation within 24 hours of hospital admission were identified and compared with a matched cohort of patients not receiving thiamine. The primary objective was to determine if thiamine administration was associated with a reduced time to lactate clearance in septic shock. Secondary outcomes included 28-day mortality, acute kidney injury, and need for renal replacement therapy, and vasopressor and mechanical ventilation-free days. Two-thousand two-hundred seventy-two patients were screened, of whom 1,049 were eligible. The study consisted of 123 thiamine-treated patients ...Continue Reading

References

Jan 1, 1988·Intensive Care Medicine·A M CruickshankA Shenkin
Jan 1, 1993·European Journal of Clinical Pharmacology·C M TallaksenJ Karlsen
Feb 7, 1998·Medical Care·A ElixhauserR M Coffey
Nov 20, 1998·Archives of Surgery·J SchröderF Stüber
Nov 28, 2001·The American Journal of Clinical Nutrition·R F Butterworth
Aug 18, 2004·Critical Care : the Official Journal of the Critical Care Forum·Rinaldo BellomoUNKNOWN Acute Dialysis Quality Initiative workgroup
Mar 22, 2006·Evidence-based Complementary and Alternative Medicine : ECAM·Derrick Lonsdale
Jul 22, 2010·Journal of Critical Care·Michael W DonninoLong Ngo
Sep 14, 2011·Current Opinion in Clinical Nutrition and Metabolic Care·William Manzanares, Gil Hardy
Jun 14, 2013·Statistics in Medicine·Arvid Sjölander, Sander Greenland
Jan 15, 2014·Journal of Critical Care·Nara Aline CostaMarcos Ferreira Minicucci
Jan 16, 2016·Critical Care Medicine·Michael W DonninoUNKNOWN Center for Resuscitation Science Research Group
Feb 24, 2016·JAMA : the Journal of the American Medical Association·Mervyn SingerDerek C Angus
Apr 2, 2017·Intensive Care Medicine·Rinaldo BellomoAntoine Schneider
Apr 23, 2017·Clinical Chemistry and Laboratory Medicine : CCLM·Jake T B CollieRinaldo Bellomo
Aug 30, 2017·Journal of Critical Care·Mathias Johan HolmbergMichael William Donnino
Apr 3, 2018·Journal of Thoracic Disease·Seung Mok RyooUNKNOWN Korean Shock Society (KoSS) Investigators

❮ Previous
Next ❯

Citations

Oct 13, 2018·Critical Care Medicine·Paul E Marik
Jan 18, 2019·Critical Care Medicine·Titilope O OlanipekunRichard Snyder
Jan 18, 2019·Critical Care Medicine·Jordan A Woolum, Alexander H Flannery
Feb 6, 2019·Current Opinion in Anaesthesiology·Mark E Nunnally, Arpit Patel
Mar 14, 2019·Journal of Pediatric Endocrinology & Metabolism : JPEM·Ragaa Abd-Elsalam MohamedRadwa Saeed Ibrahim
Jul 19, 2019·Journal of Intensive Care Medicine·Farid SadakaJacklyn O'Brien
Sep 5, 2019·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Halden F Scott
Jan 18, 2020·JAMA : the Journal of the American Medical Association·Andre C Kalil
Apr 14, 2020·Journal of Intensive Care Medicine·Jacob C Jentzer, Steven M Hollenberg
May 29, 2019·Critical Care Nursing Quarterly·Jacob P CountsG Morgan Jones
Sep 17, 2020·Journal of Pharmacy Practice·Melissa Chudow, Beatrice Adams
Sep 22, 2019·Seminars in Cardiothoracic and Vascular Anesthesia·Patrick J ColemanJonathan H Chow
Feb 11, 2020·The Journal of Trauma and Acute Care Surgery·Saskya ByerlyRishi Rattan
Dec 10, 2019·European Journal of Clinical Pharmacology·Afsaneh NoormandiAlireza Abdollahi
May 12, 2020·Frontiers in Endocrinology·Gianfranco Umberto Meduri, George P Chrousos
Mar 1, 2019·Current Opinion in Anaesthesiology·Mark E Nunnally, Arpit Patel
Apr 16, 2019·American Journal of Respiratory and Critical Care Medicine·Luciano GattinoniJohn J Marini
Jul 6, 2019·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Scott L WeissRobert A Berg
Apr 16, 2019·Critical Care Medicine·Jordan A Woolum, Alexander H Flannery
Jun 27, 2019·Journal of Pharmacy Practice·Erenie GuirguisElena Tkachuk
Apr 16, 2019·Critical Care Medicine·Jayshil J Patel, Paul Bergl
Jan 16, 2020·Journal of Clinical Medicine·Jong Eun ParkSung Yeon Hwang
Nov 29, 2020·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·David LegouisSophie de Seigneux
Dec 16, 2020·Journal of Intensive Care Medicine·Pierre KoryPaul E Marik
Dec 18, 2020·Anesthesiology·Richard M Pino, Jaskaran Singh
Jan 1, 2021·Journal of Tropical Pediatrics·Kumar Manish RajArushi Gahlot Saini
Jan 16, 2021·Journal of Diabetes·Sandra Elisa Adami Batista GonçalvesDaniella Cabral de Freitas
Oct 8, 2020·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Paidi Ramakrishna ReddyBoggu Rajyalakshmi
Oct 8, 2020·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Zubair U MohamedVidya Menon
Sep 3, 2019·Annals of Emergency Medicine·Gabriel WardiChristopher Tainter
Mar 25, 2021·American Journal of Physiology. Gastrointestinal and Liver Physiology·Subrata SabuiHamid M Said
Jun 24, 2021·Progress in Transplantation : Official Publication, North American Transplant Coordinators Organization ... [et Al.]·Robert S ReamJeremy S Garrett
Apr 27, 2021·American Journal of Physiology. Endocrinology and Metabolism·K M O'ConnorF B McDonald
Jun 13, 2021·Journal of Critical Care·Yub Raj SedhaiMarkos G Kashiouris
Jul 2, 2021·Critical Care : the Official Journal of the Critical Care Forum·Khalid Al SulaimanGhassan Al Ghamdi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.