Effect of thiamine administration on metabolic profile, cytokines and inflammatory markers in drug-naïve patients with type 2 diabetes.

European Journal of Nutrition
Manuel González-OrtizMaria G Ramos-Zavala

Abstract

To evaluate the effect of thiamine administration on metabolic profile, cytokines and inflammatory markers in drug-naïve patients with type 2 diabetes mellitus (T2DM). A randomized, double-blind, placebo-controlled, pilot-scale clinical trial was carried out in 24 patients with T2DM. Twelve subjects received thiamine orally (150 mg), once daily during a fasting state for 1 month. An additional 12 patients (control group) were given placebo for the same period of time. Before and after the intervention, fasting glucose, A1C, creatinine, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides, very low-density lipoprotein, high-sensitive C-reactive protein, interleukin 6, tumor necrosis factor-alpha, leptin and adiponectin levels were estimated. Wilcoxon's signed-rank and Mann-Whitney U test were used for statistical analyses. There were significant decreases in glucose (6.7 ± 1.0 mmol/l vs. 6.0 ± 1.0 mmol/l, p = 0.024) before and after the intervention, respectively, and leptin concentrations (32.9 ± 13.3 ng/ml vs. 26.9 ± 12.8 ng/ml, p = 0.027) before and after the intervention, respectively, with thiamine administration. There were no changes with the rest of the measurements....Continue Reading

References

Jul 29, 2003·Diabetes·Roya Babaei-JadidiPaul J Thornalley
Jan 29, 2008·Current Diabetes Reviews·Paul J Thornalley
Sep 4, 2008·Journal of Periodontology·George L King
Oct 18, 2008·Journal of the American College of Cardiology·Seth S MartinMuredach P Reilly

❮ Previous
Next ❯

Citations

Sep 26, 2013·European Journal of Medical Research·Nasser M Al-DaghriShaun Sabico
May 23, 2015·Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics·Yuji KanekoYuzo Mizuno
Sep 4, 2014·Journal of Medicinal Food·Sandra Maria BarbalhoMilton Groppo
Feb 20, 2014·Clinical Medicine Insights. Endocrinology and Diabetes·Omar Al-AttasShaun Sabico
Jul 11, 2018·The British Journal of Nutrition·Xiaohua PanBenhai Xiong
Jan 29, 2020·International Journal of Food Sciences and Nutrition·Yanjun WuDongfeng Zhang
Jul 30, 2020·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Elaheh AmiraniAlireza Abed
Sep 17, 2020·Nutrients·Federico PaceiChiara Colombo
Jan 8, 2013·Molecular and Cellular Biochemistry·João Soeiro TeodoroCarlos Marques Palmeira
Nov 20, 2020·Food & Function·Amalia E YanniVaios T Karathanos
Jun 7, 2021·Acta Diabetologica·Elena BeltramoMassimo Porta
Jul 21, 2021·Menopause : the Journal of the North American Menopause Society·Hai Duc Nguyen, Min-Sun Kim

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.