PMID: 708554Sep 1, 1978Paper

Effect of thiamylal on the sensitivity of glycerinated cardiac fibres to calcium

British Journal of Anaesthesia
N IwatsukiK Iwatsuki


Clarification of the mechanisms of the myocardial depression produced by thiamylal was sought by studying the effect of thiamylal upon the sensitivity of contractile proteins to calcium (Ca2+), by using glycerinated muscle fibres from the canine right ventricle. The dose--response relationship between the concentration of Ca2+ and the force of contraction of the glycerinated cardiac muscle fibres was not shifted from the control curve by the administration of thiamylal 67 microgram ml-1. This result suggests that the changes in the sensitivity of contractile proteins to Ca2+ are not responsible for the depression of myocardial performance produced by thiamylal.


Mar 1, 1984·Canadian Anaesthetists' Society Journal·M PierrotM Cupa

Related Concepts

Depression, Chemical
Canis familiaris
Dose-Response Relationship, Drug
Muscle Proteins
Myocardial Contraction
Thiamylal sodium

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