PMID: 14409737Dec 1, 1959Paper

Effect of thioacetamide on rat liver regeneration. II. Nuclear RNA in mitosis

The Journal of Biophysical and Biochemical Cytology
R G KLEINFELD, E VON HAAM

Abstract

The effect of thioacetamide on dividing cells of regenerating rat liver has been studied. Rats were given daily subcutaneous injections of thioacetamide as a 1 per cent solution at a dosage of 5 mg./100 gm. body weight for 7 to 10 days, subjected to partial hepatectomy, and sacrificed 28 to 31 hours later. Thioacetamide treatment results in striking increases in the nuclear ribonucleoproteins of the liver cell without affecting the mitotic rate during regeneration (14). During mitosis, RNA-containing particles were seen within the spindle and coating the contracted chromosomes from prophase through metaphase or early anaphase. At telophase, prior to the reconstruction of the nuclear membrane, fine RNA-containing granules appeared within the compact chromosomal groups. These coalesced to form nucleoli corresponding in number to the number of nucleolar organizer regions. The nuclei and nucleoli showed a rapid increase in size during the reconstruction period when compared with corresponding figures of the control liver samples. Electron micrographs of interphase nucleoli indicated a similar basic granular structure in both drug-treated and control animals. The question is raised as to whether the increased nucleolar material mere...Continue Reading

References

Sep 1, 1954·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·K R PORTER
Sep 25, 1957·The Journal of Biophysical and Biochemical Cytology·J B CAULFIELD
Jan 1, 1958·Zeitschrift für Zellforschung und mikroskopische Anatomie·G YASUZUMIM SUGIOKA
Nov 25, 1958·The Journal of Biophysical and Biochemical Cytology·J G LAFONTAINE
Feb 1, 1959·Experimental Cell Research·S OHNOR KINOSITA

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Citations

Jan 1, 1969·The Journal of Cell Biology·S G Phillips, D M Phillips
Jun 1, 1972·The Journal of Cell Biology·S G Phillips
Mar 1, 1973·The Journal of Cell Biology·M K Clark, P A Dahm
Jan 1, 1989·Journal of Cancer Research and Clinical Oncology·P G GervasiG Malvaldi
Jan 1, 1968·Scandinavian Journal of Gastroenterology·A Rodriguez OllerosA A Delanoy
Oct 1, 1964·Experimental Cell Research·D SCOTT, H J EVANS
May 1, 1979·Experimental Cell Research·S G Phillips, D M Phillips
Sep 15, 1961·Klinische Wochenschrift·J BRODEHL
Oct 1, 1965·Experimental and Molecular Pathology·K Miyai, J W Steiner
Nov 1, 1978·Experimental Cell Research·A Lepoint, G Goessens

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