Effect of thrombectomy on oedema progression and clinical outcome in patients with a poor collateral profile.

Stroke and Vascular Neurology
Gabriel BroocksUta Hanning

Abstract

The impact of the cerebral collateral circulation on lesion progression and clinical outcome in ischaemic stroke is well established. Moreover, collateral status modifies the effect of endovascular treatment and was therefore used to select patients for therapy in prior trials. The purpose of this study was to quantify the effect of vessel recanalisation on lesion pathophysiology and clinical outcome in patients with a poor collateral profile. 129 patients who had an ischaemic stroke with large vessel occlusion in the anterior circulation and a collateral score (CS) of 0-2 were included. Collateral profile was defined using an established 5-point scoring system in CT angiography. Lesion progression was determined using quantitative lesion water uptake measurements on admission and follow-up CT (FCT), and clinical outcome was assessed using modified Rankin Scale (mRS) scores after 90 days. Oedema formation in FCT was significantly lower in patients with vessel recanalisation compared with patients with persistent vessel occlusion (mean 19.5%, 95% CI: 17% to 22% vs mean 27%, 95% CI: 25% to 29%; p<0.0001). In a multivariable linear regression analysis, vessel recanalisation was significantly associated with oedema formation in FCT...Continue Reading

References

Dec 10, 2002·Archives of Neurology·Hassan Kassem-Moussa, Carmelo Graffagnino
Aug 6, 2009·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Deepu R PillaiFelix Schlachetzki
Feb 12, 2015·The New England Journal of Medicine·Mayank GoyalUNKNOWN ESCAPE Trial Investigators
May 30, 2015·Stroke; a Journal of Cerebral Circulation·Tolulope T SajobiMichael D Hill
Nov 20, 2016·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Anna Mm BoersUNKNOWN MR CLEAN trial investigators †
Aug 11, 2017·Stroke; a Journal of Cerebral Circulation·Marcelo Rocha, Tudor G Jovin
Oct 26, 2018·Stroke; a Journal of Cerebral Circulation·Joon-Tae KimJeffrey L Saver
Jan 11, 2019·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Gabriel BroocksAndre Kemmling
Mar 13, 2019·Brain : a Journal of Neurology·Gabriel BroocksAndre Kemmling
Nov 2, 2019·Journal of Neurology·Gabriel BroocksUta Hanning

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