Effect of thrombocytapheresis on blood rheology in healthy donors: role of nitric oxide

Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis
Melek Bor-KucukatayVural Kucukatay

Abstract

Platelet transfusions are increasingly being used to treat thrombocytopenic conditions. Because of anticoagulation, changes in blood composition and extracorporeal circulation, donor apheresis may cause alterations in hemorheology. This study aimed at investigating the effects of thrombocytapheresis on donor blood rheology. The effect of nitric oxide (NO) on donor red blood cell (RBC) deformability after thrombocytapheresis was also studied. Platelets were collected by a Haemonetics MCS 3p cell seperator. Blood samples were obtained before and 15 min after thrombocytapheresis. RBC deformability and aggregation were measured using an ektacytometer, whole blood viscosity (WBV) was determined with a cone-plate rotational viscometer. Donor RBCs were shown to be less deformable at all stress levels except 0.30 Pa after thrombocytapheresis and NO donor sodium nitroprusside (SNP, 10(-6) M) reversed the reduced deformability caused by thrombocytapheresis. It was observed that donor apheresis induces a decrement in RBC aggregation and WBV measured at standard hematocrit (Hct). No significant alterations were observed in WBV values determined at native Hct values. Thrombocytapheresis also resulted in a decrement in fibrinogen, total prot...Continue Reading

References

Jan 1, 1990·Critical Reviews in Oncology/hematology·T ShigaK Kon
Sep 1, 1990·Blood Reviews·J Stuart, G B Nash
Jan 1, 1985·Scandinavian Journal of Thoracic and Cardiovascular Surgery·T HirayamaG William-Olsson
Mar 1, 1994·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·S M RazavianJ Levenson
Oct 15, 1993·Thrombosis Research·A VayáJ Aznar
Mar 30, 1993·European Journal of Pharmacology·R Korbut, R J Gryglewski
Feb 1, 1996·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·S J SweetT Callahan
Mar 1, 1994·Biorheology·E Friederichs, H J Meiselman
Feb 1, 1997·Artificial Organs·Y TakamiY Nosé
Jan 22, 1998·The American Journal of Physiology·T OonishiN Uyesaka
Aug 13, 1999·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·M V KamenevaH S Borovetz
May 18, 2001·American Journal of Physiology. Heart and Circulatory Physiology·R M BatemanC G Ellis
Jan 11, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Melek Bor-KucukatayOguz K Baskurt

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Citations

Jul 3, 2020·Journal of Evidence-based Medicine·Alejandro Gil-BetancurJaiberth Antonio Cardona-Arias
Dec 26, 2019·Scientific Reports·Alejandro Gil-BetacurJaiberth Antonio Cardona-Arias

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