PMID: 3933144Oct 1, 1985Paper

Effect of thyroid hormones on liver microsomal enzyme induction in rats exposed to 2,3,7,8,-tetrachlorodibenzo-p-dioxin

Toxicology
Karl K RozmanA Parkinson

Abstract

The effect of thyroidectomy and thyroid hormone replacement therapy on liver microsomal enzyme induction was studied in 2,3,7,8,-tetrachlorodibenzo-p-dioxin (TCDD)-treated rats (100 micrograms/kg). Treatment of non-thyroidectomized rats with TCDD had no effect on the concentration of liver microsomal cytochrome b5. In contrast, cytochrome b5 content was increased by TCDD treatment of thyroidectomized rats, regardless of replacement therapy with either T3 or T4. TCDD treatment increased the concentration of cytochrome P-450 (2-3-fold) and the activities of benzo[a]pyrene hydroxylase (4-7-fold), ethoxyresorufin O-de-ethylase (50-70-fold) and UDP-glucuronosyltransferase (5-7-fold) in non-thyroidectomized and thyroidectomized as well as thyroidectomized thyroid hormone treated rats; indicating the induction of these liver microsomal enzyme activities is independent of thyroid status. Because thyroid status alters the toxicity of TCDD but does not alter the ability of TCDD to induce microsomal enzymes, it appears that TCDD toxicity may not be directly related to microsomal enzyme induction.

References

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Citations

Jan 1, 1987·Archives of Environmental Contamination and Toxicology·R J AulerichA C Napolitano
Jun 15, 1986·Toxicology and Applied Pharmacology·C L PotterR E Peterson
Jan 1, 1986·Toxicology Letters·K RozmanA Parkinson
Jun 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·P BullockA Parkinson
Feb 21, 2006·Biochemical Pharmacology·Patricia A HarperAllan B Okey
Jan 15, 1987·Biochemical Pharmacology·C K KellingR E Peterson
Nov 1, 2014·Expert Review of Endocrinology & Metabolism·Kingsley Ibhazehiebo, Noriyuki Koibuchi
Nov 20, 2018·EFSA Journal·UNKNOWN EFSA Panel on Contaminants in the Food Chain (CONTAM)Laurentius Ron Hoogenboom

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