PMID: 8952005Nov 14, 1996Paper

Effect of thyroid hormones on pituitary neuromedin B and possible interaction between thyroid hormones and neuromedin B on thyrotropin secretion

Regulatory Peptides
Tania M Ortiga-CarvalhoCarmen Cabanelas Pazos-Moura

Abstract

Neuromedin B (NB), a bombesin-like peptide, has been recently characterized as a physiological paracrine/autocrine inhibitor of thyrotropin (TSH) secretion. We hypothesized on the basis of our prior experiments that thyroid hormones stimulate pituitary NB secretion which mediates, at least in part, the TSH-suppressive effect of thyroid hormone. Here, we evaluated the time-course of the effect of thyroid hormones administration to eu- and hypothyroid rats on the anterior pituitary content of NB and on serum TSH. As previously reported, the pituitary content of NB increased in hyperthyroidism and decreased in hypothyroidism. Chronic treatment of hypothyroid rats with a physiological dose of thyroxine (0.8 microgram/100 g b.w. s.c, for 3 or 5 days) normalized pituitary NB content, while 5 days of treatment with a pharmacological dose of thriiodothyronine (0.4 microgram/100 g b.w.) induced an increase above that of normal pituitaries. Thyroxine and triiodothyronine injected once, s.c., into hypothyroid rats required 30 min to normalize NB content, which reached higher than normal values in 3-6 h. At these times, the increment in NB preceded or was simultaneous with the suppression of serum TSH. This rapid and marked effect on pitui...Continue Reading

References

Apr 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·V RettoriS M McCann
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Citations

Dec 21, 2002·Life Sciences·Rachel Moraes MoreiraCarmen C Pazos-Moura
Oct 3, 2000·Thyroid : Official Journal of the American Thyroid Association·F H CurtyC C Pazos-Moura
Apr 18, 2003·Thyroid : Official Journal of the American Thyroid Association·Carmen C Pazos-MouraEgberto Gaspar de Moura
Mar 10, 2010·The Journal of Physiology·Gabriela Silva Monteiro PaulaCarmen Cabanelas Pazos-Moura
Oct 13, 2007·Regulatory Peptides·Karen J OliveiraCarmen C Pazos-Moura
Dec 13, 2006·Metabolism: Clinical and Experimental·Christina Nogueira AragãoCarmen Cabanelas Pazos-Moura
Sep 17, 2015·Journal of the Science of Food and Agriculture·Thaiane G GaiqueKaren J Oliveira
Jul 21, 2011·Regulatory Peptides·Ricardo Henrique Costa-e-SousaCarmen Cabanelas Pazos-Moura
Oct 14, 2016·Archives of Endocrinology and Metabolism·Fábio V G CampanhaCélia R Nogueira
Dec 9, 2010·Journal of Preventive Medicine and Public Health = Yebang Ŭihakhoe Chi·Elisabete Weiderpass
Jul 7, 2011·Journal of the History of the Behavioral Sciences·Robert Van Horn, Matthias Klaes
Dec 22, 2004·Arquivos brasileiros de endocrinologia e metabologia·Egberto G de Moura, Carmen C Pazos de Moura
Oct 8, 2003·Experimental Biology and Medicine·Tânia Maria Ortiga-CarvalhoCarmen Cabanelas Pazos-Moura

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