PMID: 6981030Jun 1, 1982Paper

Effect of thyroidectomy on the rat adrenal cortex enzyme activities involved in corticosterone and aldosterone biosynthesis

Journal of Steroid Biochemistry
C BenelliR Michel

Abstract

The effect of thyroidectomy on corticosterone and aldosterone biosynthesis, in rat adrenal cortex, were investigated in vitro. Thyroidectomy slowed down by about 30% the activity of microsomal 21 hydroxylase and mitochondrial 11 beta hydroxylase, the two stages leading to corticosterone formation from progesterone. The plasma corticosterone concentration also diminished in thyroidectomized rat. The mitochondrial enzyme system catalyzing the conversion of corticosterone into aldosterone included both 18 hydroxylase and 180H dehydrogenase. In the absence of thyroid hormone, values of both enzyme activity slowed down by about 30%. Thus thyroidectomy induced a general decrease in all mitochondrial hydroxylation processes requiring NNADPH as energetic cofactor. Mitochondrial NADPH was mainly synthesized by the activity of NADP+ malic enzyme and pyridine nucleotide transhydrogenase; the activity of both enzymes was determined in submitochondrial particles from adrenal cortex of normal and thyroidectomized rats. The activity of NADP+ malic enzyme and non energy-dependent transhydrogenase in the direction of NADPH formation dropped significantly after thyroidectomy, thus reducing the amount of NADPH available for hydroxylating mechanis...Continue Reading

References

Mar 3, 1975·Biochemical and Biophysical Research Communications·J G Lehoux, J C Forest
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Dec 17, 1971·Biochemical and Biophysical Research Communications·J RydströmL Ernster
Jun 1, 1972·The Journal of Clinical Endocrinology and Metabolism·T F GallagherD K Fukushima
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Jun 1, 1982·Journal of Steroid Biochemistry·C BenelliR Michel
May 1, 1972·FEBS Letters·D R. PfeifferT T. Tchen
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Jan 1, 1963·Endocrinology·B G STEINETZ, V L BEACH
May 15, 1957·Proceedings of the National Academy of Sciences of the United States of America·E G Ball, O Cooper

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