Effect of thyroxin on cell morphology and hormone secretion of pituitary grafts in rats.

Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft
Matilde LombarderoKalman Kovacs

Abstract

Growth hormone and prolactin secretion is affected by thyroid hormones. To see if this influence is subsidiary to the hyptothalamus, we investigated the effects of thyroxin (T4) on hormone secretion and histology of sellar pituitaries and pituitary grafts detached from the hypothalamus (autografted or allografted under the kidney capsule). Male Wistar rats were divided into eight groups: control, thyroidectomised, pituitary autografted, pituitary allografted, and four additional groups that were injected with T4 for two weeks, starting four weeks after surgery. At sacrifice, adenohypophysial hormone blood levels were assessed, and tissue from sellar and grafted pituitaries were investigated by histology and electron microscopy. Growth hormone and prolactin blood levels, as well as the number of growth hormone immunopositive cells increased in T4-treated groups. Both pituitary auto- and allo-grafts showed lactotroph hyperplasia and displayed spongiform areas containing cells with vesicles in their cytoplasm resembling thyroidectomy cells. This phenomenon was minimized in their respective T4-treated group. Thyroidectomy cells were identified in pituitary grafts, indicating that hypothalamic control was not essential to induce the...Continue Reading

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Citations

Jul 16, 2021·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Laphatrada YurasakpongAthikhun Suwannakhan

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