Effect of thyroxine on permeability of the neonatal rat lung to drugs

Biology of the Neonate
J A Hemberger, L S Schanker

Abstract

The effect of thyroxine (1-2 microgram/g i.p. on days 1-4 after birth) on development of adult-type permeability characteristics in the lung was investigated in rats 6-18 days of age. In both treated and control rats, the lipid-soluble drug procaine amide was absorbed at similar rates in all age groups. In contrast, in thyroxine-treated animals, pulmonary absorption rates for the lipid-insoluble compounds mannitol and p-aminohippuric acid declined to adult levels at age 6-12 days, 6 days earlier than in controls. Thyroxine treatment thus accelerates development of adult permeability characteristics in the pulmonary epithelium.

Citations

Dec 6, 2011·Experimental and Molecular Pathology·D Radford Shanklin
Sep 1, 1980·The Anatomical Record·K R Hitchcock

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