Effect of thyroxine, testosterone, and corticosterone on nerve growth factor (NGF) and epidermal growth factor (EGF) concentrations in adult female mouse submaxillary gland: dissociation of NGF and EGF responses

Endocrinology
P WalkerD A Fisher

Abstract

Testosterone propionate (TP) and corticosterone acetate (CA) were administered alone and in combination with T4 to assess the effect on submaxillary gland (SMG) nerve growth factor (NGF) and epidermal growth factor (EGF) concentrations in adult female mice. Mice were treated for 5 or 10 days. SMG NGF, and EGF concentrations were measured by specific RIA techniques. Mean SMG NGF (0.68 +/- 0.08 microgram/mg protein) and EGF (0.58 +/- 0.05 microgram/mg protein) concentrations were similar in control mice. T4 (0.4 microgram/g BW, sc, daily) significantly increased mean SMG NGF and EGF concentrations to 469% and 347%, respectively, of control values after 5 days and to 1190% and 568%, respectively, after 10 days of treatment. TP (25 microgram/g BW, sc, every 2 days) significantly increased mean SMG NGF and EGF concentrations to 734% and 767%, respectively, of control values at 5 days and to 1971% and 1953%, respectively, at 10 days. T4 and TP resulted in no further significant increases in either SMG NGF or EGF concentrations above the levels observed after TP alone. CA (25 microgram/g BW, sc, daily) increased mean SMG NGF, but not EGF, concentrations at both 5 and 10 days. Moreover, T4 and CA appeared to exert an additive effect on...Continue Reading

Citations

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