Effect of thyroxine treatment on epididymal carbohydrate metabolism in the pubertal rat

International Journal of Andrology
B M PereiraP Govindarajulu

Abstract

The influence of thyroxine treatment on key enzymes involved in the glycolytic and HMP shunt pathways was studied in the caput, corpus and cauda epididymides of pubertal rats, and related to the serum hormone profile. The activity of 6-phosphofructokinase and pyruvate kinase was significantly increased in all 3 segments of the epididymis, but the HMP shunt pathway was suppressed. Thyroxine treatment was found to depress the serum levels of testosterone, LH and FSH, although an increase in prolactin levels was observed. Withdrawal of hormone treatment resulted in the restoration of normal activity of 6-phosphofructokinase and pyruvate kinase and restoration of normal serum hormone levels. However, the activity of glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase increased following withdrawal of treatment. It is concluded that hyperthyroidism exerts an influence on epididymal enzymes involved in carbohydrate metabolism.

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Citations

Jul 21, 1998·International Journal of Andrology·R R MaranP Govindarajulu
Jul 17, 2001·International Journal of Andrology·R R MaranM M Aruldhas
Jul 5, 2006·Orphanet Journal of Rare Diseases·Yves Lacasse, Yvon Cormier
Dec 22, 1999·The Veterinary Record·A M Mayenco-AguirreM A Daza
Jan 1, 1985·Archives of Andrology·U S SinghM V Kumar

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