Abstract
1 In anaesthetized cats and dogs treated with mecamylamine, the pressor response to McN-A-343 was increased when the animals were changed from a supine to a head-up, tilted position. This potentiation was not seen in rats. 2 The potentiation of the McN-A-343 pressor response was not affected by propranolol, destruction of the brain, or removal of the intestines, spleen or adrenal glands. It was promptly abolished by applying pressure to the lower half of the tilted animal. No increase in the pressor response to McN-A-343 occurred when cats were tilted head down. The potentiated response in tilted cats was abolished by atropine. 3 The pressor effects of adrenaline, noradrenaline, tyramine and angiotensin in cats treated with mecamylamine were either reduced or unchanged when the animal was changed from the supine to the tilted position. In one cat not treated with mecamylamine in which orthostatic hypotension occurred, tilting potentiated the pressor responses to dimethyl phenylpiperazinium iodide. 4 In cats anaesthetized with chloralose, the reflex pressor response to bilateral carotid occlusion was reduced by tilting. After mecamylamine treatment the residual atropine-sensitive response to carotid occlusion was potentiated whe...Continue Reading
References
Nov 1, 1976·European Journal of Pharmacology·C Chinn, J G Hilton
Jul 1, 1967·Acta Physiologica Scandinavica·J K JansenL Walloe
Jun 1, 1969·Circulation Research·A M Brown
Jun 1, 1969·British Journal of Pharmacology·S O Kayaalp, R J McIsaac
Oct 1, 1970·Biulleten' eksperimental'noĭ biologii i meditsiny·A I BasaevaM F Vialykh
Aug 1, 1967·Circulation Research·G GlickE Braunwald
Feb 1, 1969·British Journal of Pharmacology·J R Vane
Nov 1, 1974·British Journal of Pharmacology·R FieldenE M Taylor
Dec 1, 1971·The American Journal of Physiology·J W ConstantineS C Wang
Jan 1, 1966·The American Journal of Physiology·N L BrowseJ T Shepherd
Sep 1, 1954·Circulation·M H KALSERA S GORDON
Jan 1, 1956·Circulation Research·F J HADDY, R P GILBERT
Oct 1, 1961·Acta Physiologica Scandinavica·B FOLKOWS MELLANDER
Jan 1, 1962·Circulation·F J HADDYE C TEXTER
Feb 1, 1963·Annals of Internal Medicine·N P DEPASQUALE, G E BURCH
Nov 1, 1950·The American Journal of Physiology·W A FREYBURGERG K MOE
Dec 1, 1950·The American Journal of Physiology·W A FREYBURGERG K MOE