Effect of time and duration of untreated psychosis on cognitive and social functioning in Chinese patients with first-episode schizophrenia: A 1-year study

Nordic Journal of Psychiatry
Anisha Heeramun-AubeeluckZheng Lu

Abstract

Duration of untreated psychosis (DUP) is believed to exert a deleterious effect on cognitive and social function. However, to date, results remain inconclusive. To investigate the effect of time and DUP on cognitive and social functioning in first-episode schizophrenia (FES) subjects in Shanghai, China. FES patients were subjected to a comprehensive neuropsychological battery, the Personal and Social Performance scale (PSP) and the Positive and Negative Symptoms Scale (PANSS) at baseline, 6 month and 1 year. DUP was defined as the time from onset of first psychotic symptoms to first contact made with psychiatric services. Though the rate of non-completers in our observational study was relatively high (40%), we did not find any significant differences between the completers and non-completers (P-values > 0.05). Significant impairments in verbal learning and memory and executive function were noted over the course of 1 year. Meanwhile, social function improved significantly over the course of 1 year. Although, DUP did not share any significant relationship with cognitive or social function the effect estimate (range: - 0.03 to 0.02) of an increase of 1 month in DUP was clinically non-negligible in this study. In Chinese FES pati...Continue Reading

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Citations

Oct 9, 2016·Neuroscience Letters·Andrea Murru, Bernardo Carpiniello
Oct 13, 2016·Early Intervention in Psychiatry·Catherine Shiu-Yin ChongWilliam Tak-Lam Lo
May 10, 2017·Issues in Mental Health Nursing·Abd Alhadi Hasan, Mahmoud Musleh
Mar 31, 2018·Early Intervention in Psychiatry·Ruth L FirminJenifer L Vohs

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