Effect of timing and duration of dietary conjugated linoleic acid on mammary cancer prevention

Nutrition and Cancer
C IpH J Thompson

Abstract

Conjugated linoleic acid (CLA) is a minor fatty acid found predominantly in the form of triglycerides in beef and dairy products. Previous work by Ip and co-workers showed that free fatty acid-CLA at < or = 1% in the diet is protective against mammary carcinogenesis in rats. The present study verified that the anticancer activities of free fatty acid-CLA and triglyceride-CLA are essentially identical. This is an important finding, because it rules out a nonspecific free fatty acid effect. In terms of practical implication, we can continue the in vivo research with the less-expensive free fatty acid-CLA without compromising the physiological relevance of the data. A primary objective of this report was to investigate how the timing and duration of CLA feeding might affect the development of mammary carcinogenesis in the methylnitrosourea (MNU) model. We found that exposure to 1% CLA during the early postweaning and pubertal period only (from 21 to 42 days of age) was sufficient to reduce subsequent tumorigenesis induced by a single dose of MNU given at 56 days of age. This period incidentally corresponds to a time of active morphological development of the mammary gland to the mature state. In contrast to the above observation, ...Continue Reading

Citations

May 12, 2005·Journal of Mammary Gland Biology and Neoplasia·Airo TsuburaNobuaki Shikata
Feb 1, 1997·Lipids·M A Belury, A Kempa-Steczko
Jul 14, 1998·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J A Scimeca
Nov 24, 1999·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·P A JonesR U Pendlington
Feb 7, 2001·Cancer Letters·N E HubbardK L Erickson
Apr 18, 2000·Mutation Research·H TsudaM A Moore
Sep 26, 2003·The Proceedings of the Nutrition Society·Klaus W J WahleSteven D Heys
Jun 18, 2005·The Proceedings of the Nutrition Society·Sabine TriconParveen Yaqoob
Sep 27, 2005·Critical Reviews in Food Science and Nutrition·Tilak R DhimanAmy L Ure
Jun 9, 2005·Critical Reviews in Food Science and Nutrition·Ki Won LeeYoung Jun Kim
Dec 19, 2002·Journal of Medicinal Food·Claude L Hughes, Tilak R Dhiman
Dec 21, 2005·Acta Veterinaria Hungarica·G SzölloskeiF Husvéth
Feb 2, 2012·Journal of Nutritional Science and Vitaminology·Kenta SatoIkuo Ikeda
Dec 2, 2014·Obesity Research & Clinical Practice·Kazunori Koba, Teruyoshi Yanagita
Jun 19, 2007·European Journal of Pharmacology·Sun Jin Hur, Yeonhwa Park
May 4, 2011·Journal of Food Science·Anna NuddaGiuseppe Pulina
Apr 2, 2015·Journal of Food Science and Technology·Cem Okan Özer, Birol Kiliç
Oct 2, 2008·Lipids in Health and Disease·Spiros N ZlatanosAngelos Sagredos
Nov 4, 2000·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·L D WhighamR L Atkinson
Dec 29, 2000·Bioscience, Biotechnology, and Biochemistry·M YamasakiK Yamada
Nov 9, 2010·Food Microbiology·Maria SchironeGiovanna Suzzi
Mar 18, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Lillian BarrosIsabel C F R Ferreira
Nov 15, 2001·Animal Health Research Reviews·P R O'QuinnM D Tokach
Sep 1, 2009·Progress in Lipid Research·Philippe BougnouxStephan Chevalier

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