PMID: 7372356Jan 1, 1980Paper

Effect of timing of cefuroxime dosage on its protection of rats against gentamicin nephrotoxicity

Infection
K Capel-EdwardsR D Foord

Abstract

The neophrotoxic effect on rats of once daily treatment with 40 or 45 mg gentamicin/kg/day for ten days was substantially reduced by administration of 4 g cefuroxime/kg/day, either at the same time or eight hours later. This dosage of cefuroxime was protective when given for only two consecutive days starting on the first to third days of gentamicin treatment, but enhanced gentamicin nephrotoxocity when started on the sixth or subsequent days.

References

Jul 1, 1978·Antimicrobial Agents and Chemotherapy·B G PettyP S Lietman
May 1, 1978·The Journal of Antimicrobial Chemotherapy·M BarzaT Murray
Oct 1, 1977·Antimicrobial Agents and Chemotherapy·J S WoldN V Owen
May 1, 1976·Antimicrobial Agents and Chemotherapy·F C LuftS A Kleit
Jan 1, 1975·The Journal of Antimicrobial Chemotherapy·R D Foord
Jan 1, 1976·Antimicrobial Agents and Chemotherapy·P DellingerL Weinstein
Apr 1, 1976·Antimicrobial Agents and Chemotherapy·P DellingerL Weinstein
May 1, 1966·Toxicology and Applied Pharmacology·R M AtkinsonE G Tomich

❮ Previous
Next ❯

Citations

Oct 26, 1999·Pediatrics International : Official Journal of the Japan Pediatric Society·H WakiguchiT Kurashige
Aug 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·K H WolfeW H Li
Sep 6, 2005·Biological & Pharmaceutical Bulletin·Atsushi IshikadoTaketoshi Makino
Aug 2, 2007·Chemical & Pharmaceutical Bulletin·Chikako TakedaYoshiharu Machida
Sep 11, 2007·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Kiyomi Takase, Izuru Kakuta
Oct 4, 2011·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Kiyomi Takase, Izuru Kakuta
Mar 1, 1982·Pflügers Archiv : European journal of physiology·W Jelkmann
Sep 1, 2006·Environmental Health and Preventive Medicine·Mitsuyo MakitaMasaharu Yamamoto

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.