Effect of timing of iron supplementation on maternal and neonatal growth and iron status of iron-deficient pregnant rats

The Journal of Physiology
Lorraine GamblingHarry J McArdle

Abstract

We have previously shown that maternal iron (Fe) deficiency not only reduces fetal size, but also increases blood pressure in the offspring when they are adults. In this paper we examine whether there are critical periods when supplementation reverses or fails to reverse the effect both on size and on expression of genes of Fe metabolism. We made dams Fe deficient, mated them and provided supplements of Fe in the diet from the beginning of gestation (0.5 days), from 7.5 days or from 14.5 days. Within 12 h of birth, dams and neonates were killed and tissues taken and examined. Fe deficiency throughout pregnancy reduces neonatal size. Supplementation from the beginning of the first, second or third week all reduced the effect. Maternal haematocrit was restored to normal levels only in animals given supplements for at least 2 weeks. In contrast, the neonates' Fe levels were normal in all supplemented groups. These results were mirrored in liver Fe levels and in transferrin receptor mRNA. Iron-responsive element (IRE)-regulated divalent metal transporter 1 (DMT1) increased in maternal and neonatal liver. Non-IRE-regulated DMT1 levels did not change in the maternal liver, but decreased in the neonatal liver. H and L ferritin mRNA le...Continue Reading

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Citations

May 26, 2012·Biological Trace Element Research·Jinyan FuLiegang Liu
Jan 1, 2009·Indian Journal of Clinical Biochemistry : IJCB·Neeta KumarPratik Kumar
Feb 12, 2008·International Journal of Epidemiology·Mandy B BelfortMatthew W Gillman
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Nov 2, 2013·The Proceedings of the Nutrition Society·Harry J McArdleChristine Kennedy
May 5, 2016·The Journal of Nutritional Biochemistry·Sarah C CottinHarry J McArdle
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Oct 11, 2017·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Kaylee K HelfrichSusan M Smith
Apr 27, 2018·Journal of Neuroscience Research·Karen P FloresPamela J Kling
Jan 30, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Lorraine GamblingHarry J McArdle
May 6, 2011·The American Journal of Clinical Nutrition·Lorraine GamblingHarry J McArdle
Sep 24, 2019·Journal of Developmental Origins of Health and Disease·William D ReesHarry J McArdle
Jun 8, 2018·The Journal of Nutrition·Sean LynchDaniel J Raiten
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Jul 28, 2020·The Journal of Reproduction and Development·Shingo TonaiYasuhisa Yamashita
Feb 5, 2021·Frontiers in Cellular Neuroscience·Maude BordeleauMarie-Ève Tremblay

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