Effect of Timolol on Aqueous Humor Outflow Facility in Healthy Human Eyes

American Journal of Ophthalmology
Arash KazemiArthur J Sit

Abstract

Hyposecretion of aqueous humor has been postulated to adversely affect the health of the trabecular meshwork and outflow resistance. However, the effect of medications that reduce aqueous humor production on outflow facility in living human eyes is unclear. This study evaluated the effect of timolol, an aqueous humor flow suppressant, on outflow facility in healthy eyes. Prospective, before-and-after study. In a multicenter study, 113 healthy participants over 40 years of age were included. Intraocular pressure (IOP) was measured with the participant in the sitting position by using a pneumatonometer. The outflow facility was measured with the participant in the supine position by 2-minute pneumatonography. After participants self-administered drops of timolol 0.5% for 1 week, twice daily in each eye, both measurements were repeated. Mean IOP decreased from 15.1 ± 3.0 mm Hg at baseline to 12.4 ± 2.4 mm Hg (P < 0.001) after 1 week of timolol use. Mean outflow facility decreased from 0.23 ± 0.08 μL/min/mm Hg at baseline to 0.18 ± 0.08 μL/min/mm Hg (P < 0.001) after timolol. The change in outflow facility was negatively correlated with baseline outflow facility (r = -0.51; P < 0.001). Timolol reduces outflow facility in healthy hu...Continue Reading

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Jan 24, 2017·Investigative Ophthalmology & Visual Science·Arash KazemiArthur J Sit

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Citations

Feb 27, 2019·Investigative Ophthalmology & Visual Science·Ying Ying SunKate E Keller
May 23, 2019·Investigative Ophthalmology & Visual Science·Peyman Davvalo KhongarRodolfo Repetto
Nov 13, 2019·ACS Nano·Mohamed Moustafa IbrahimMonica M Jablonski

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