Effect of timolol versus propranolol on hypertension and hemodynamics

Circulation
W S AronowJ Cassidy

Abstract

The effect of timolol versus propranolol on hypertension, hemodynamics, and plasms renin activity was evaluated in 20 men. After two weeks of placebo, 11 men received timolol 30 to 60 mg daily, and nine men received propranolol, 240 to 480 mg daily, for five weeks in a double-blind randomized study. The 20 men then received placebo again for two weeks. Right heart catheterization was performed in all 20 patients after two weeks of the first placebo and after five weeks of timolol or propranolol. Equipotent doses of timolol and propranolol were equally effective in significantly lowering supine and upright systolic and diastolic blood pressure and heart rate recorded on an outpatient basis. Equipotent doses of timolol and propranolol caused similar hemodynamic effects including similar significant depression of cardiac index. Equipotent doses of timolol and propranolol caused similar marked depression of plasma renin activity. The hypotensive action of timolol and of propranolol was unrelated to their effect on plasma renin activity.

References

Jan 9, 1975·The New England Journal of Medicine·E L BravoH P Dustan
Apr 1, 1975·American Heart Journal·G Lohmöller, E D Frohlich
Aug 1, 1975·Clinical Pharmacology and Therapeutics·J A Franciosa, E D Freis
Apr 1, 1975·British Journal of Clinical Pharmacology·T O MorganA E Doyle
Nov 6, 1975·The New England Journal of Medicine·J Koch-Weser
Jan 12, 1974·British Medical Journal·G S StokesI R Thornell
Mar 23, 1972·The New England Journal of Medicine·R ZacestJ Koch-Weser
Jun 1, 1974·Archives of Internal Medicine·J Koch-Weser
Apr 1, 1973·Minerva cardioangiologica·B MagnaniM Sanguinetti
May 1, 1973·British Heart Journal·P A MajidS H Taylor
May 1, 1974·Clinical Pharmacology and Therapeutics·M D Esler
Mar 1, 1968·Circulation·E D FrohlichI H Page
Jan 4, 1969·British Medical Journal·B N Prichard, P M Gillam

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Citations

Dec 18, 1978·European Journal of Clinical Pharmacology·O F ElseI R Edwards
Oct 25, 1979·The New England Journal of Medicine·I M Katz
Jun 17, 1982·The New England Journal of Medicine·W H Frishman
Jul 1, 1981·British Heart Journal·J FerlinzW S Aronow
Jul 1, 1978·American Journal of Ophthalmology·W P BogerD Pavan-Langston
Jan 1, 1985·Clinical and Experimental Hypertension. Part A, Theory and Practice·M A van BaakJ F Smits
Jan 1, 1979·Current Problems in Cardiology·C V Ram, N M Kaplan
Nov 10, 1983·The American Journal of Cardiology·U Thadani
Jun 1, 1983·International Journal of Cardiology·M D EzriM E Josephson
Mar 1, 1980·Clinical and Experimental Pharmacology & Physiology·A ScriabineN R Bohidar

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