PMID: 7382911Feb 1, 1980

Effect of tinidazole on the oral, throat, and colon microflora of man

Medical Microbiology and Immunology
A HeimdahlK Okuda

Abstract

Tinidazole in capsules was given orally in doses of 150 mg twice per day for 7 days to ten subjects. Saliva, throat, and faecal specimens were taken up to 16 days after administration for cultivation of aerobic and anaerobic bacteria and for assay of tinidazole. Mean peak serum levels of tinidazole varied between 3.3 microgram/ml to 5.4 microgram/ml. The saliva concentrations of tinidazole were between 2.9 microgram/ml to 5.9 microgram/ml. No concentration of tinidazole was detected in faeces. In saliva, a slight decrease in the numbers of fusobacteria was found, but no other changes in the oral, throat, or colon microflora were observed.

References

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Citations

Sep 1, 1991·Journal of Veterinary Pharmacology and Therapeutics·E SarkialaM Mero
May 15, 1984·The American Journal of Medicine·C E NordA Heimdahl
Feb 1, 1987·The British Journal of Oral & Maxillofacial Surgery·L BorthenC E Nord
Jan 1, 1983·Scandinavian Journal of Infectious Diseases·A Heimdahl, C E Nord
Aug 1, 1990·Journal of Chemotherapy·C E Nord, C Edlund
Jan 1, 1982·Scandinavian Journal of Infectious Diseases·A Heimdahl, C E Nord

Related Concepts

Microcapsules Drug Delivery System
Taenia Coli
Antibiotic Resistance, Microbial
Feces
Buccal Mucosa
Nitroimidazoles
Pharyngeal Structure
Saliva
Tricolam

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Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Allergy & Infectious Diseases

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

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