PMID: 24344544Dec 19, 2013Paper

Effect of TiO2 nanofibres on selected bronchoalveolar parameters in acute and subacute phase--experimental study

Central European Journal of Public Health
M HurbánkováStefánia Moricová

Abstract

Titanium dioxide nanofibres (TiO2) were intratracheally instilled in dose of 4 mg/0.2 mL saline solution per animal (Wistar rats). After 48 hours and 14 days the animals were exsanguinated (under i.p. thiopental narcosis), bronchoalveolar lavage (BAL) was perfomed and cells from BAL fluid were isolated. Following inflammatory, cytotoxic and oxidative stress BAL parameters were examined: differential cell count (% of alveolar macrophages (AM), polymorphonuclears and lymphocytes); the viability and phagocytic activity of AM; the proportion of immature cells; the proportion of multinucleated cells; count of AM/mL lavage; count of BAL cells/mL lavage; the level of ascorbic acid and activity of superoxide dismutase, both in tissue homogenate and in bronchoalveolar lavage fluid. The majority of examined BAL parameters in the acute and subacute phase in our study suggest serious inflammatory and cytotoxic processes in lung after exposure to TiO2.

References

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Citations

Jul 1, 2017·Central European Journal of Public Health·Pavel BulejkoVladimír Bencko
Jan 18, 2017·Central European Journal of Public Health·Stanislav KukaZuzana Tatarková
Nov 13, 2016·Reviews on Environmental Health·Marta HurbankovaStefania Moricova
Oct 1, 2020·Central European Journal of Public Health·Marta HurbánkováŠtefánia Moricová
Jun 18, 2020·Journal of Exposure Science & Environmental Epidemiology·Karin LovénUNKNOWN NanoLund
Nov 13, 2018·Central European Journal of Public Health·Marta HurbánkováŠtefánia Moricová
Dec 9, 2015·Occupational and Environmental Medicine·D PelclovaS Zakharov
Mar 22, 2016·PloS One·Manfredi AllegriEnrico Bergamaschi

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