Effect of Titanium Dioxide Nanoparticle Exposure on the Ocular Surface: An Animal Study

The Ocular Surface
Youngsub EomHyo Myung Kim

Abstract

To evaluate the effect of titanium dioxide (TiO2) nanoparticle exposure on the ocular surface. Eighty eyes of 40 rabbits were used. The TiO2-1D group (n = 20) received a single instillation of TiO2 in the right eye. The TiO2-4D group (n = 20) received a TiO2 instillation in the right eye once a day for four days. The 40 untreated left eyes were used as controls. Ocular surface staining (n = 5 for each group) was performed with rose bengal dye, tear secretion (n = 5) was measured using the phenol red thread test, lactic dehydrogenase (LDH) activity (n = 5) and MUC5AC levels (n = 5) were measured in tears, and the area of the conjunctival goblet cells (n = 5) was measured through impression cytology and scanning electron microscopy 24 hours after the last TiO2 instillation. Ocular surface staining was increased but the tear secretion was not changed after TiO2 exposure. The TiO2-1D (1.39 OD) and TiO2-4D groups (0.58 OD) had higher median tear LDH activity than the control groups (0.57 OD and 0.29 OD, respectively). Although the median tear MUC5AC level in the TiO2-1D group (92.7 ng/ml) was higher than that of control 1 group (37.4 ng/ml), there was no significant difference in MUC5AC levels between the TiO2-4D and control 2 group...Continue Reading

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Citations

Jul 20, 2018·Investigative Ophthalmology & Visual Science·Xiangzhe LiJong Suk Song
Jan 17, 2019·Investigative Ophthalmology & Visual Science·Xiangzhe LiJong Suk Song
Sep 23, 2018·Investigative Ophthalmology & Visual Science·Gabrielle GomartArnaud Sauer
Aug 28, 2019·Advanced Science·Shuang ZhuYuliang Zhao

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