Effect of Tobacco Smoking Cessation on C-Reactive Protein Levels in A Cohort of Low-Dose Computed Tomography Screening Participants

Scientific Reports
Silvano GallusUgo Pastorino

Abstract

Smokers have higher levels of C-Reactive Protein (CRP) compared to never smokers. The role of smoking cessation on CRP is still under debate. Using data from two screening studies conducted in Italy in 2000-2010 on 3050 heavy smokers (including 777 ex-smokers), we estimated multivariate odds ratios (OR) for high CRP (i.e. ≥2 mg/L) according to smoking status. Moreover, in a longitudinal analysis based on 975 current smokers, with a second measurement of CRP after an average study period of 3.4 years, we estimated the changes in CRP according to smoking cessation. Prevalence of high CRP at baseline was 35.8% among ex-smokers and 41.1% among current smokers (significant OR for ex- vs. current smokers: 0.79). After four years since smoking cessation, CRP levels significantly decreased with increasing years of cessation (significant OR for ex-smokers since more than 8 years: 0.55). In the longitudinal analysis, no significant reduction in CRP was found for time since smoking cessation (ORs: 1.21, 1.04, and 0.91 for ex-smokers since 1 year, 2-3 years, and ≥4 years, respectively). In the largest prospective study available so far, we found that smoking cessation has a favourable effect on CRP, but this benefit is not evident in the s...Continue Reading

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Citations

Feb 27, 2020·Aging·Alejandro Santos-LozanoAlejandro Lucia
Oct 1, 2020·BMC Cardiovascular Disorders·Pascal B MeyreSven Knecht
Feb 28, 2021·Neuroscience and Biobehavioral Reviews·Radhouene DogguiAlex Baldacchino
Apr 23, 2021·Porto Biomedical Journal·Patrícia TavaresRita Ferreira
May 19, 2021·Respirology : Official Journal of the Asian Pacific Society of Respirology·Miguel Ángel Martinez-GarciaAlvar Agusti
Jun 16, 2021·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Lena AnderssonHåkan Westberg
Aug 18, 2021·Metabolic Syndrome and Related Disorders·Diana Rodríguez-VeraRodolfo Pinto-Almazán
Jul 23, 2021·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Carol H ChristensenCindy M Chang
Nov 19, 2021·American Journal of Human Biology : the Official Journal of the Human Biology Council·Ashley W KranjacOlivia Lounsbury

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