Apr 1, 1976

Effect of tobramycin on urinary gamma-glutamyltransferase activity: Studies in a case of renal carcinoma

Clinical Chemistry
P R Beck, A K Chaudhuri

Abstract

Gamma-Glutamyltransferase activity was studied in a man presenting with recurrent septicemia owing to pyonephrosis and renal carcinoma. Increased activity in the urine was ascribable to administration of the aminoglycoside antibiotic, tobramycin. That the renal carcinoma did not contribute to the increased values was confirmed by homogenization and enzyme histochemistry of the tumor. Although the activity of this enzyme in serum was greater than normal, this persisted postoperatively, and thus was not related to the renal carcinoma.

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Mentioned in this Paper

Septicemia
Urine
Renal Carcinoma
Gamma-glutamyl transferase
Carcinomatosis
Nephrectomy
Gamma-glutamyltransferase Activity
Structure of Cortex of Kidney
Tobramycin Measurement
Antibiotics, Aminoglycoside

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