Effect of topical administration of antiinflammatory drugs to rats with adjuvant arthritis.

Arthritis and Rheumatism
R D Heilman, R R Reo

Abstract

Oral or intramuscular administration of antiinflammatory agents produces numerous undesirable side effects. This work explores the hypothesis that topical administration of such agents directly to the site of inflammation would have beneficial antiinflammatory effects. Topical administration of steroidal and nonsteroidal antiinflammatory drugs to rats with adjuvant arthritis was as effective as oral or intramuscular administration. Peak blood levels of radioactivity following administration of equal doses of hydrocortisone-3H were considerably lower after topical administration than after oral administration.

References

Sep 1, 1971·Proceedings of the Society for Experimental Biology and Medicine·D T WalzH Friedman
Jan 1, 1969·The Journal of Investigative Dermatology·R J Feldmann, H I Maibach
Aug 1, 1963·Journal of Chronic Diseases·C M PEARSON
Aug 1, 1963·British Journal of Pharmacology and Chemotherapy·B B NEWBOULD

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Citations

Jun 1, 1980·Agents and Actions·D L Larson, J G Lombardino
Apr 8, 1998·The Journal of Pharmacy and Pharmacology·S A MikulakM E Nimni

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