Effect of topical alendronate treatment on fixation of implants inserted with bone compaction

Clinical Orthopaedics and Related Research
Thomas JakobsenK Søballe

Abstract

Bone compaction has been shown to enhance the critical initial implant stability that is important for secure long-term fixation. We investigated whether topical bisphosphonate treatment improves fixation of implants inserted with bone compaction. Porous-coated titanium implants were inserted with bone compaction into the knees of eight dogs. In the right knee, topical bisphosphonate treatment was applied before bone compaction. Saline was used as a control in the left knee. The knees were observed for 4 weeks. We found an increase in total bone-to-implant contact and total bone density around the implants in the bisphosphonate-treated group. These were results of increased nonvital bone-to-implant contact and increased nonvital periimplant bone density. No change in biomechanical fixation was found. Studies with a longer followup are needed to investigate whether the preservative effect of alendronate on nonvital bone might enhance implant fixation by osteoconduction.

References

Mar 1, 1992·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·K SøballeC Bünger
Jan 1, 1992·Journal of Biomedical Materials Research·W J DhertP M Rozing
May 1, 1982·The Anatomical Record·D B Kimmel, W S Jee
Sep 1, 1996·The Journal of Arthroplasty·M A ChannerT P Vail
Feb 2, 1999·The Journal of Arthroplasty·J R GreenM S Balas
Nov 24, 1999·The Journal of Clinical Investigation·L I PlotkinT Bellido
May 18, 2000·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·S OvergaardG Gundersen
Jan 25, 2002·Clinical Orthopaedics and Related Research·Keerati ChareancholvanichWilliam D Lew
Feb 28, 2002·The Journal of Bone and Joint Surgery. American Volume·Yuichi MochidaPhillip R Brown
Mar 7, 2002·Breast Cancer Research : BCR·Herbert Fleisch
Mar 12, 2004·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Jörgen Astrand, Per Aspenberg
Mar 30, 2004·Biomaterials·Gun-Il ImArun S Shanbhag
May 6, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Satoshi KomatsubaraHiromichi Norimatsu
Feb 3, 2005·Clinical Orthopaedics and Related Research·Søren KoldKjeld Søballe
Mar 2, 2005·Clinical Orthopaedics and Related Research·Søren KoldKjeld Søballe
Jul 19, 2005·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Søren KoldKjeld Søballe

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Citations

Jul 14, 2010·Journal of Biomedicine & Biotechnology·Jessica A CottrellJ Patrick O'Connor
Mar 24, 2012·BMC Musculoskeletal Disorders·David A BackStefan H Greiner
Oct 3, 2008·The Journal of Bone and Joint Surgery. American Volume·Sanjeev J SuratwalaFrancis Young-In Lee
Jul 15, 2015·Maxillofacial Plastic and Reconstructive Surgery·Ho-Chul KimSang-Hun Shin
Apr 4, 2017·International Journal of Oral and Maxillofacial Surgery·S V KellesarianF Javed
Nov 15, 2017·BMC Musculoskeletal Disorders·Thomas JakobsenOle Rahbek
Aug 30, 2008·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Thomas JakobsenKjeld Søballe
Mar 13, 2008·Journal of Biomedical Materials Research. Part a·Kasra ZainaliKjeld Soballe
Dec 21, 2006·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Thomas JakobsenKjeld Søballe
Jan 9, 2010·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Fang-Bing ZhuRui Li
Dec 15, 2015·The Open Orthopaedics Journal·Thomas JakobsenOle Rahbek
Sep 11, 2012·The Open Orthopaedics Journal·Thomas JakobsenKjeld Søballe
Jul 17, 2015·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Thomas JakobsenJørgen Baas
May 2, 2009·The Journal of Bone and Joint Surgery. British Volume·F Agholme, P Aspenberg
Aug 1, 2012·Journal of Biomedical Materials Research. Part a·Kasra ZainaliKjeld Soballe
Jul 11, 2007·Clinical Orthopaedics and Related Research·Thomas JakobsenKjeld Søballe
Nov 2, 2019·Hip International : the Journal of Clinical and Experimental Research on Hip Pathology and Therapy·Theofilos S KarachaliosGeorge A Komnos

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