PMID: 9423903Jan 10, 1998Paper

Effect of topical anti-transforming growth factor-beta on corneal stromal haze after photorefractive keratectomy in rabbits

Journal of Cataract and Refractive Surgery
S B ThomJ A Gomes

Abstract

To determine the relationship between anti-transforming growth factor-beta (anti-TGF-beta) antibodies and the amount of corneal stromal haze after excimer laser photorefractive keratectomy (PRK). Wills Eye Hospital, Philadelphia, Pennsylvania, USA. Nineteen rabbits had bilateral PRK. Dichlorotriazinyl fluorescein was used to stain the exposed stroma; all rabbits were then treated with antibiotic ointment for 4 days. Ten rabbits were randomized to treatment with topical anti-TGF-beta1, -beta2, and -beta3 antibody 50 microg three times a day for 4 days; the others received diluent three times a day for 4 days. Stromal haze was graded weekly for 8 weeks on a 0 to 4+ scale. At the end of the study, all corneas were examined histopathologically. All treated eyes developed appreciable haze. Seven control rabbits and one antibody-treated rabbit had an epithelial erosion (P = .00001). Antibody-treated rabbits had significantly less haze at 3, 4, and 5 weeks (right eyes) and 3, 4, 5, 7 and 8 weeks (left eyes) (P < .05). Histopathology and fluorescence microscopy showed subepithelial collagen deposition consistent with clinical haze. Topical anti-TGF-beta antibody reduced stromal haze after PRK in the rabbit model and may be clinically b...Continue Reading

References

Mar 1, 1992·Journal of Clinical Immunology·S M Wahl
Jan 1, 1992·Progress in Growth Factor Research·N A NobleW A Border
Jan 1, 1992·Journal of the National Medical Association·M L Walker
Jul 1, 1992·The Journal of Clinical Investigation·W A Border, E Ruoslahti
Apr 15, 1990·American Journal of Ophthalmology·R A Del PeroD M Taylor
May 1, 1990·Archives of Ophthalmology·F E FantesM Savoldelli
Jun 1, 1990·Archives of Ophthalmology·M B McDonaldH E Kaufman
Jun 1, 1989·Archives of Ophthalmology·K D HannaM Menasche
Apr 1, 1995·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·A AbrahamianJ H Rockey
Mar 1, 1995·Ophthalmology·B A NassarallaP J McDonnell
Mar 1, 1994·Journal of Leukocyte Biology·N L McCartney-Francis, S M Wahl
Jul 1, 1993·The American Journal of the Medical Sciences·R A Clark
Jan 1, 1993·The Journal of Experimental Medicine·S M WahlJ R Dasch
Jan 1, 1993·International Review of Experimental Pathology·T G TerrellJ D Green
Nov 1, 1995·Journal of Cataract and Refractive Surgery·M Pop, M Aras

❮ Previous
Next ❯

Citations

Jun 19, 2004·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·T HammerE Peschke
Mar 14, 2000·Journal of Cataract and Refractive Surgery·Y KajiH Yamashita
Mar 14, 2000·Journal of Cataract and Refractive Surgery·P Fagerholm
Mar 22, 2002·Progress in Retinal and Eye Research·M Francesca Cordeiro
Jun 13, 2002·Acta Ophthalmologica Scandinavica·Heather C Baldwin, John Marshall
Nov 1, 2002·International Ophthalmology Clinics·Eric D DonnenfeldSeth Biser
Aug 8, 2002·Current Opinion in Ophthalmology·Mohammad H Dastjerdi, H Kaz Soong
Sep 17, 2002·Journal of Cataract and Refractive Surgery·Federico Castro-MuñozledoWalid Kuri-Harcuch
May 18, 2007·Molecular Biology of the Cell·Audrey M BernsteinSandra K Masur
Apr 8, 2015·Current Eye Research·Marina KoulikovskaPer Fagerholm
Jun 25, 2005·Journal of Cataract and Refractive Surgery·Jong-Suk SongHyo-Myung Kim
Jul 22, 2014·Veterinary Ophthalmology·Michael K FinkRajiv R Mohan
Mar 17, 2011·Journal of Cataract and Refractive Surgery·Chyong Jy NienJames V Jester
Jul 4, 2013·Acta Ophthalmologica·Nick J R Maycock, John Marshall
Feb 7, 2002·Cardiovascular Drug Reviews·J Chamberlain
Dec 28, 2018·Npj Regenerative Medicine·Lisa J HillLiam M Grover
May 3, 2006·Lancet·Tohru SakimotoDimitri T Azar
Sep 8, 2009·Brain Research Bulletin·Fu-Shin X YuJenny Huang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.