Abstract
This study investigated the effect of topical application of 2% chlorhexidine (GCl) and metronidazole (Gme) pastes for the repair of palatal wounds in rats. A 4-mm diameter wound was created on the palates of 27 rats separated randomly into 3 groups of 9 animals each, according to the treatment received: GNa (Control: natrosol), GCl, and GMe. The animals were euthanized after 3, 6, and 10 days, and wound closure was clinically and histomorphometrically assessed. Clinical evaluation showed a statistically significant difference in tissue repair with GCl and GMe compared with GNa. In histomorphometric analysis, the highest values in the areas of the epithelium and keratin were observed for GCl and GMe; however, compared with Gna, no statistically significant differences were observed. GCl and GMe pastes showed promising results with regard to tissue repair from a clinical point of view. Histologically, premature closure of wounds was noted in most specimens on day 6. Although no statistically significant differences were observed among the experimental groups with regard to histometry of the epithelium and keratin, the highest means were observed for GCl.
References
Jul 1, 1976·Scandinavian Journal of Dental Research·J Langebaek, L Bay
Mar 1, 1989·Journal of Periodontal Research·P J OosterwaalH H Renggli
Jun 1, 1989·Journal of Periodontology·S R SouthardD E Tira
Oct 1, 1989·Journal of Periodontology·M SanzC Saltini
Nov 1, 1988·Veterinary Surgery : VS·I R SanchezJ A McGuire
Jun 1, 1986·Journal of Periodontology·G GreensteinR Jaffin
Jan 1, 1986·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·R A SaatmanP J DeBaecke
Jan 1, 1970·Journal of Periodontal Research·J LindheC R Schiott
Aug 1, 1993·Journal of Periodontology·M H ShahanJ C McPherson
Aug 26, 1998·Journal of Periodontology·T LieO E Böe
Feb 28, 2006·British Dental Journal·D ReekieH Devlin
Feb 21, 2007·Journal of Clinical Periodontology·Avital KozlovskyLiat Reich
Nov 6, 2007·Toxicology in Vitro : an International Journal Published in Association with BIBRA·M GiannelliA Tani
Jan 25, 2008·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Yuichiro HataHiroyuki Ishikawa
Jan 27, 2009·International Journal of Oral and Maxillofacial Surgery·D KosuticG Knezevic
Aug 8, 2009·Clinical Oral Investigations·Maria Consuelo CousidoPedro Diz
Jan 14, 2011·International Journal of Dental Hygiene·H M HammadM S Khalifeh
Dec 6, 2011·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·P K MianiV Pedrazzi
Aug 21, 2013·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Ela Tules FiratErsin Uysal