PMID: 9449171Jan 1, 1997Paper

Effect of topical corticosteroids on the activity of superoxide dismutase in human skin in vitro

Skin Pharmacology : the Official Journal of the Skin Pharmacology Society
N Gavan, H Maibach

Abstract

We measured the superoxide dismutase (SOD) activity in human skin from tissue homogenates after topical application of hydrocortisone-21-acetate and clobetasol proprionate, dissolved in propylene glycol. SOD was measured spectrophotometrically. SOD activity was higher in the treated skin than in the control untreated skin. We separated epidermis from the dermis by curettage and measured the level of SOD in each homogenized layer; SOD activity was higher in the epidermis compared to the dermis in untreated skin. After corticoid application, SOD activity was higher in the dermis compared to the epidermis to a degree dependent on corticoid potency. These experiments demonstrate that the epidermis may have a role in the barrier function of the skin by its antioxidant capacity and that the dermis is the major location of the metabolic activity in the skin. On the other hand, our results suggest that these corticosteroids may stimulate SOD production and may release antioxidants. This could be another anti-inflammatory property of corticosteroids.

Citations

Jan 8, 2013·Pediatric Surgery International·Paiboon SookpotaromPaisarn Vejchapipat
Jun 23, 2006·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Jung Won LeeSeung Joo Lee
Aug 21, 2009·The Journal of Urology·Jennie J MickelsonEarl Y Cheng
Aug 24, 1999·The Journal of Urology·M A MonsourG E Dean
May 24, 2005·Skin Pharmacology and Physiology·T HikimaH I Maibach
Sep 9, 2005·The Journal of Urology·Jeffrey S PalmerLane S Palmer
Feb 24, 2001·Journal of Hypertension·J J KellyJ A Whitworth

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