Effect of topical cyclosporin A on herpetic stromal keratitis in a mouse model

Cornea
Kyung-Chul YoonKyoung-Oh Cho

Abstract

To study the effect of topical cyclosporin A on herpetic stromal keratitis (HSK) in a mouse model. The corneas of BALB/c mice were infected with herpes simplex type 1 virus. The mice were divided into 4 groups according to topical treatment methods: vehicle solution, 0.01% cyclosporin A, 0.1% cyclosporin A, and 1% cyclosporin A. The severity of stromal keratitis was graded clinically at 3, 7, 10, and 14 days after treatment. Histologic and immunohistochemical examinations were performed to analyze infiltrating inflammatory cells and T lymphocytes at 14 days after treatment. Flow cytometry was performed to count CD4 T cells at 14 days after treatment. On day 3 after treatment, there were no significant differences in mean severity scores of HSK between the vehicle and cyclosporin A-treated groups. On days 7, 10, and 14, the severity scores in the groups treated with 0.1% or 1% cyclosporin A decreased significantly compared with the vehicle group (P < 0.05). However, the scores in the group treated with 0.01% cyclosporin A did not change up to 14 days after treatment. By histologic and immunohistochemical analysis, a significant decrease in the total number of inflammatory cells and T lymphocytes was detected in the groups treate...Continue Reading

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Oct 15, 2011·Cornea·Anna-Karina B MaierSibylle Winterhalter
Oct 16, 2015·International Ophthalmology·Mohammed ZiaeiBita Manzouri
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Jun 27, 2019·Investigative Ophthalmology & Visual Science·Ying LiKyung Chul Yoon

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