PMID: 9550347Jan 1, 1996Paper

Effect of topical cyclosporin A on Thygeson's superficial punctate keratitis

Documenta Ophthalmologica. Advances in Ophthalmology
J M Del CastilloJ Garcia-Sanchez

Abstract

Thygeson's superficial punctate keratitis (Thygeson's SPK) is a distinct clinical entity, characterized by round conglomerates of discrete, granular, white-gray, fine intraepithelial dots without conjunctival involvement. The only effective treatment with regard to relieving symptoms and diminishing lesions has been topical corticosteroids, but their prolonged use can be associated with severe side-effects. The purpose of this study is to present the long-term results of the use of 2% topical cyclosporin A in olive oil in Thygeson's SPK. Eight patients diagnosed as having Thygeson's SPK were included. All the patients were treated with 2% cyclosporin dissolved in olive oil four times a day for three months, and two times a day for one month before withdrawing therapy. The follow-up period ranged from twelve to twenty-five months. The number of corneal lesions varied between 5 and 15 before treatment. After cyclosporin treatment, no corneal lesion was observed and the cornea remained clear after the follow-up period. In conclusion, 2% cyclosporin in olive oil is a safe alternative to corticosteroids in the treatment of Thygeson's SPK, and resulted in satisfactory control of the condition.

References

Aug 1, 1979·American Journal of Ophthalmology·S L Forstot, P S Binder
Jan 1, 1974·Archives of Ophthalmology·M A LempJ Lundy
Jan 1, 1981·Ophthalmology·K F TabbaraJ Oh
Aug 1, 1953·A.M.A. Archives of Ophthalmology·A E BRALEY, R C ALEXANDER
Dec 30, 1950·Journal of the American Medical Association·P THYGESON

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Citations

Jan 9, 2004·Ophthalmology·Parveen K NagraPeter R Laibson
Sep 20, 2005·The British Journal of Ophthalmology·S Tatlipinar, E K Akpek
Mar 29, 2007·The British Journal of Ophthalmology·Paul P ConnellWilliam J Power
Jul 3, 2007·Optometry : Journal of the American Optometric Association·Robert S Duszak
Dec 17, 2019·Cornea·Samir S Shoughy, Khalid F Tabbara
Aug 26, 2010·Ocular Immunology and Inflammation·Canan Asli UtineEsen K Akpek
Oct 26, 2020·Experimental Eye Research·Kristina VossMartin Heur

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