PMID: 6162397Sep 1, 1980Paper

Effect of topical indomethacin on allergen-induced dual skin reactions

Allergy
W Dorsch, X Baur

Abstract

Twelve asthmatics with dual bronchial and skin reactions after allergen challenge received topical treatment with a 5%-indomethacin cream half an hour before and up to 7 h after intradermal allergen and histamine injections. The erythema during the first 20 min of the wheal and flare reaction (WFR) was not affected, neither were the diameters of wheals and flares. 40 to 60 min after injection we observed a marked reduction of the erythema in histamine- and allergen-tested skin areas of 10 patients. This effect lasted up to the 5th h after injection of high allergen doses. During the fully developed late cutaneous reactions (LCR) no effect of indomethacin on the erythema was observed, the edema of LCR was only insignificantly reduced. These results suggest that the erythema in LCR between the 1st and 4th h is caused, at least in part, by local formation of prostaglandins.

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Citations

Mar 1, 1982·Prostaglandins, Leukotrienes, and Medicine·A J Fairfax
Feb 1, 1990·British Journal of Clinical Pharmacology·F Humphreys, S Shuster
Nov 1, 1993·Clinical and Experimental Dermatology·C B Archer
May 1, 1990·The Journal of Allergy and Clinical Immunology·R Grönneberg, S E Dahlén
Jan 1, 1984·The British Journal of Dermatology·C B ArcherD M MacDonald
Sep 1, 1983·International Journal of Dermatology·R F Lemanske, M A Kaliner
Jan 1, 1985·Allergy·R Grönneberg, O Zetterström
Mar 1, 1987·Clinical and Experimental Dermatology·R K Curley, J L Verbov
May 1, 1991·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R Grönneberg, O Zetterström

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