Effect of topical prostaglandin D2 on the aqueous humor dynamics in rabbits.

Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
Y GohO Hayaishi

Abstract

Effects of topically applied prostaglandin (PG) D2 on the aqueous outflow facility, uveoscleral flow, and aqueous flow rate were studied in rabbits to reveal its intraocular pressure (IOP)-reducing mechanism. The outflow facility after PGD2 application (50 micrograms) as measured by 2-min tonography was 0.19 microliters/min/mm Hg and did not differ from that before the application (0.22) or from that of the control contralateral eye (0.21). Direct measurement of the uveoscleral flow by perfusion of the anterior chamber for 30 min with fluorescein isothiocyanate-labeled dextran solution showed the flow rate to be about 0.15 microliters/min in indomethacin-treated (10 mg/kg, i.p.) rabbits. In these animals, PGD2 (50 micrograms) was ineffective in changing the flow rate, while PGF2 alpha (50 micrograms) significantly increased the flow by about 35%. Indirect assessment of the effects of PGs on this flow system was made using the uveoscleral flow-antagonizing ability of topical pilocarpine (1.5 mg). IOP reduction by PGD2 (50 micrograms) was only slightly inhibited by pilocarpine, while that by PGF2 alpha (10 micrograms) was markedly reduced. Aqueous flow rate measured fluorophotometrically was about 3.5 microliters/min in normal ey...Continue Reading

References

Jun 1, 1988·The British Journal of Ophthalmology·Y GohO Hayaishi
Nov 1, 1987·Experimental Eye Research·M E Langham, N Edwards
Jul 1, 1966·Experimental Eye Research·R F Jones, D M Maurice
Jan 1, 1966·Documenta Ophthalmologica. Advances in Ophthalmology·A Bill
Jun 1, 1983·Journal of Medicinal Chemistry·G L BundyW L Miller

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Citations

Jan 1, 1991·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·M NakajimaO Hayaishi
Jan 19, 1993·European Journal of Pharmacology·D F WoodwardA L Nieves
Feb 27, 2004·European Journal of Pharmacology·Takashi KonnoNorimichi Nakahata
Aug 8, 1998·Progress in Retinal and Eye Research·A Alm
May 26, 2006·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Carol B TorisMarsha A McLaughlin
Feb 7, 2016·Experimental Eye Research·Mark JohnsonDarryl R Overby
Aug 7, 2012·Acta Ophthalmologica·Sidse KringelholtToke Bek
Feb 8, 2014·Current Eye Research·Tomoyuki IsobeSohei Tanabe
Jun 17, 1998·Experimental Eye Research·Y TakashimaN Yoshimura
Feb 3, 2005·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Naj A SharifTerry L Davis
Mar 25, 2008·Therapeutics and Clinical Risk Management·Robert J Noecker
May 24, 2020·Microscopy Research and Technique·İsmail Hakkı NurHaluk Testereci
Mar 1, 1991·Current Eye Research·O A CandiaT C Chu

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