PMID: 9418951Jan 7, 1998Paper

Effect of topically applied sulphur mustard on guinea pig liver

Journal of Applied Toxicology : JAT
R S Chauhan, L V Murty

Abstract

The study revealed that topically applied sulphur mustard, which is a potent blistering agent with mutagenic and carcinogenic properties, is also hepatotoxic. It produces severe steatosis and other pathological alterations, accompanied by biochemical changes. There is a significant rise in the levels of glutamic oxaloacetic transaminase (GOT) and glutamic pyruvate transaminase (GPT) after exposure. The liver injury appeared to peak on the third day. Recovery at the ultrastructural level could be noticed on the sixth day but was far from complete because the gross pathological changes were still severe.

Citations

Jan 29, 2013·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Seyed Mansour RazaviMohammad Abdollahi
Apr 18, 2013·Cutaneous and Ocular Toxicology·Hassan GhasemiTooba Ghazanfari
Feb 6, 2013·Journal of Hazardous Materials·Camilla Della TorreEzio Amato
Sep 26, 2008·Basic & Clinical Pharmacology & Toxicology·Jaroslav PejchalJiri Kassa
Dec 8, 2014·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Dinesh G GoswamiRajesh Agarwal
Aug 4, 2016·Journal of Receptor and Signal Transduction Research·Mohammad Reza NouraniAbbas Ali Imani Fooladi

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