Effect of traditional Chinese medicinal enemas on ulcerative colitis of rats

World Journal of Gastroenterology : WJG
Song-Ming GuoWei Yang

Abstract

To investigate the effects of traditional Chinese medicinal enema (TCME) on inflammatory and immune response of colonic mucosa of rats with ulcerative colitis (UC), and to observe the pathogenic mechanism. Thirty UC rats, induced by intestinal enema together with 2.4-dinitrochlorobenzene (DNCB) and acetic acid, were randomly divided into 3 groups, i.e., GI, GII and GIII. Groups GI and GII were administered with TCME and salazosulfapyridine enema (SASPE), respectively. Group GIII was clystered with only normal saline (NSE), served as control. Group GIV was taken from normal rats as reference, once daily, from the 7th day after the establishment of UC for total 28 d. Interleukin-6 (IL-6) in the colonic mucosa was assayed by (3)H-TdR incorporation assay. Colonic mucosal lymphocyte subpopulation adhesive molecules, CD(4)(+)CD(11a )(+), CD(4)(+)CD(18)(+), CD(8)(+)CD(11a)(+), CD(8)(+)CD1(18)(+) (LSAM), tumor necrosis factor (TNF)-alpha, and interferon-gamma (IFN-gamma), were detected by enzyme linked immunosorbent assay (ELISA). Moreover, the expression of TNF-alpha mRNA and IFN-gamma mRNA in colonic mucosa were detected by polymerase chain reaction (RT-PCR). Before therapies, in model groups, GI, GII and GIII, levels of IL-6, TNF-al...Continue Reading

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Citations

Jul 12, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Eunyoung SongJinhyeok Kwon
May 6, 2014·Current Treatment Options in Oncology·Maciej SałagaJakub Fichna

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