PMID: 15333480Aug 31, 2004Paper

Effect of training status on regional disposal of circulating free fatty acids in the liver and skeletal muscle during physiological hyperinsulinemia

Diabetes Care
Patricia IozzoJuhani Knuuti

Abstract

Fat metabolism is increasingly implicated in the pathogenesis of type 2 diabetes. Endurance training has been shown to prevent hepatic steatosis and to alter skeletal muscle fat metabolism, and regional free fatty acid (FFA) uptake adaptations were suggested as a mechanism. Thus, we tested whether endurance training modifies the uptake of plasma FFAs occurring in the liver and in skeletal muscle during anabolic, i.e., hyperinsulinemic, conditions. Trained and untrained healthy male subjects underwent positron emission tomography scanning of the liver and thigh regions, with the FFA analog 14(R,S)-[(18)F]fluoro-6-thia-heptadecanoic acid, during euglycemic hyperinsulinemia. Tracer influx rate constants in skeletal muscle (MK(i)) and liver (LK(i)) were multiplied by plasma FFA levels to obtain FFA uptake for skeletal muscle (MFU) and liver (LFU), respectively. Athletes showed increased Vo(2max) (P < 0.0001), insulin-mediated glucose disposal (M value, 61 +/- 4 vs. 46 +/- 3 micromol. min(-1). kg(-1), P = 0.01), and plasma lactate levels during the clamp and lower percentage of body fat mass (P = 0.002). MK(i) was 25% higher in athletes than in sedentary men (P = 0.03). In all subjects, MK(i) and MFU were positively correlated with ...Continue Reading

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Citations

Jan 6, 2011·Current Opinion in Lipidology·Faidon Magkos
Aug 31, 2011·World Journal of Gastroenterology : WJG·Shira Zelber-SagiRan Oren
Oct 21, 2006·The Journal of Physiology·Jarna C HannukainenKari K Kalliokoski
Apr 29, 2005·Diabetes/metabolism Research and Reviews
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May 14, 2011·Journal of Applied Physiology·R Scott Rector, John P Thyfault
Dec 6, 2017·Journal of Labelled Compounds & Radiopharmaceuticals·Nina SavistoOlof Solin
Jul 8, 2017·Journal of Applied Physiology·Jesper Lundbom

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