Effect of transdermal nicotine administration on exercise endurance in men

Experimental Physiology
Toby Mundel, David A Jones

Abstract

Nicotine is widely reported to increase alertness, improve co-ordination and enhance cognitive performance; however, to our knowledge there have been no attempts to replicate these findings in relation to exercise endurance. The purpose of this study was to determine the effects nicotine might have on cycling endurance, perception of exertion and a range of physiological variables. With local ethics committee approval and having obtained informed consent, 12 healthy, non-smoking men (22 +/- 3 years; maximal O2 uptake, 56 +/- 6 ml kg(-1) min(-1), mean +/- s.d.) cycled to exhaustion at 18 degrees C and 65% of their peak aerobic power, wearing either a 7 mg transdermal nicotine patch (NIC) or a colour-matched placebo (PLA) in a randomized cross-over design; water was available ad libitum. Subjects were exercising at approximately 75% of their maximal O2 uptake with no differences in cadence between trials. Ten out of 12 subjects cycled for longer with NIC administration, and this resulted in a significant 17 +/- 7% improvement in performance (P < 0.05). No differences were observed for perceived exertion, heart rate or ventilation. There were no differences in concentrations of plasma glucose, lactate or circulating fatty acids. I...Continue Reading

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Citations

Sep 4, 2009·European Journal of Applied Physiology·Toby Mündel, David A Jones
Jun 19, 2008·European Journal of Applied Physiology·Rob C I WüstHans Degens
Sep 30, 2014·Scandinavian Journal of Medicine & Science in Sports·J Morente-SánchezM Zabala Díaz
Jul 30, 2014·Regulatory Toxicology and Pharmacology : RTP·M GajewskaK-W Schramm
Jan 13, 2015·American Journal of Respiratory and Critical Care Medicine·Hans DegensHieronymus W H van Hees
Jun 3, 2017·Clinical Physiology and Functional Imaging·Robert JohnstonMelissa Crowe
Jul 14, 2017·PloS One·Frida BjörkmanBjörn Ekblom
Nov 6, 2018·Scandinavian Journal of Medicine & Science in Sports·Thomas ZandonaiCristiano Chiamulera
Feb 18, 2018·European Journal of Applied Physiology·Robert JohnstonKenji Doma
Feb 28, 2018·European Journal of Applied Physiology·Toby Mündel, I Mark Olfert
Dec 23, 2006·Pharmacogenomics·Marcus Munafò, Caryn Lerman
Aug 9, 2019·Bioscience, Biotechnology, and Biochemistry·Yi-Ming ChenChien-Yu Hsiao
Apr 12, 2019·Frontiers in Physiology·Toby MündelStephen R Stannard
Dec 3, 2020·European Journal of Sport Science·Andreas M Kasper, Graeme L Close
Feb 20, 2021·Journal of the International Society of Sports Nutrition·Bao-Lien HungShih-Hua Fang

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