PMID: 8945058Nov 1, 1996Paper

Effect of transdermal scopolamine on heart rate variability in patients with severe coronary heart disease

Pacing and Clinical Electrophysiology : PACE
G E KochiadakisP E Vardas

Abstract

A decrease in cardiac parasympathetic tone is a recognized finding in patients with ischemic heart disease, correlating closely with disease severity and overall survival. The aim of this study was to assess whether transdermal scopolamine (Tds), which increases parasympathetic tone in healthy volunteers, increases vagal tone in patients with severe CAD and whether it might have an antiischemic effect. Fifteen patients (10 men, aged 55 +/- 8 years) with three-vessel CAD, but with no prior MI and preserved ventricular function, underwent 24-hour Holter monitoring and exercise testing before and after wearing a scopolamine patch for 24 hours. Time-domain measures of heart rate variability (HRV) and the total number and duration of ischemic episodes were obtained from the Holter recordings for each patient. Tds significantly (P < 0.05) increased the values of all HRV measures. Tds also reduced the total number of ischemic episodes (from 273 to 159, P < 0.05) and their total duration (from 136 to 46 min per patient, P < 0.05). Tds also increased treadmill exercise duration from 293 +/- 101 to 345 +/- 95 seconds (P < 0.05) and the time to 1-mm ST depression from 177 +/- 105 to 244 +/- 128 seconds (P < 0.02), while maximum ST depress...Continue Reading

Citations

Oct 20, 2004·Zeitschrift für Kardiologie·K Sroka
Jul 2, 2005·Expert Opinion on Investigational Drugs·G Cevc

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Related Papers

The Journal of the Association of Nurses in AIDS Care : JANAC
D J Porche
Annals of the New York Academy of Sciences
L P To
© 2021 Meta ULC. All rights reserved